The levels of cerebrospinal fluid Aβ40 and Aβ42(43) are regulated age-dependently
The levels of cerebrospinal fluid Aβ40 and Aβ42(43) are regulated age-dependently
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DOI：
10.1016/s0197-4580(00)00229-3
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发表时间：
2001-03-01
影响因子：
4.2
通讯作者：
Hirai, S
中科院分区：
文献类型：
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作者：
Shoji, M;Kanai, M;Hirai, S
脑脊液Aβ42水平降低是阿尔茨海默病S病的诊断标志。为了阐明这一标志物的生物学基础，我们研究了脑脊液Aβ40和Aβ42随年龄增长的生理变化。对92例8~89岁正常人的脑脊液标本进行了Aβ40和Aβ42(43)的特异性ELISA检测。Aβ40和Aβ42(43)在29岁以下的青年组中浓度较高，而在30~59岁的成年组中浓度较低。随后，随着年龄的增长，其水平再次升高。三阶回归分析显示Aβ40水平与年龄(Y=-169X-3+3.1X(2)-0.02X+4135；P<；0.034)和A42(43)水平与年龄(Y=-46X-3+0.9X-2-0.005X+992；P<；0.005)显著相关。正常衰老时，脑脊液A40和Aβ42(43)水平受生理调节，呈U型自然变化。这些发现表明，59岁以上的Aβ42(43)的生理性增加在阿尔茨海默病的S病中被选择性地抑制。(C)2001 Elsevier Science Inc.保留所有权利。
Decreased levels of cerebrospinal fluid (CSF) A beta 42 is a diagnostic marker of Alzheimer' s disease. To clarify the biological basis of this marker, the physiological alterations of CSF A beta 40 and A beta 42 by aging were studied. CSF samples from 92 normal subjects between 8 and 89 years old were measured using a specific ELISA for A beta 40 and A beta 42(43). High concentrations of A beta 40 and A beta 42(43) in the young group, under 29 years old, changed to be at low concentrations in the adult group between 30 and 59 years old. Subsequently, the levels increased again with age. Third order regression analysis showed a significant correlation between the levels of A beta 40 and age (Y = - 169 X-3 + 3.1X(2)- 0.02X + 4135; P < 0.034) and between the levels of A42(43) and age (Y = - 46 X-3 + 0.9 X-2- 0.005X + 992; P < 0.005). The levels of CSF A40 and A beta 42(43) were physiologically regulated to show a U-shaped natural course in normal aging. These findings suggested that the physiological increase of A beta 42(43) over 59 years of age is selectively inhibited in Alzheimer' s disease. (C) 2001 Elsevier Science Inc. All rights reserved.