A new series of coumarin derivatives having monoamine oxidase inhibitory activity from Monascus anka
A new series of coumarin derivatives having monoamine oxidase inhibitory activity from Monascus anka
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DOI：
10.1248/cpb.44.1535
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发表时间：
1996-08-01
影响因子：
1.7
通讯作者：
Yamazaki, M
中科院分区：
文献类型：
--
作者：
Hossain, CF;Okuyama, E;Yamazaki, M
Monankarins A-F(1-6)是从红曲霉中分离得到的一种新的具有吡喃-香豆素骨架的色素。通过波谱分析和化学修饰确定了它们的结构，单酚A-D具有抑制单胺氧化酶(MAO)的活性，而单酚A-D和单酚A、单酚A-D以及其他一些简单的香豆素没有观察到这种活性。在小鼠脑内，Monankarin C(3)对MAO-B的抑制作用强于MAO-A，但在小鼠肝脏对MAO-B的抑制作用不明显。
Monankarins A-F (1-6), a new series of pigments having conjugated pyrano-coumarin skeleton have been isolated from Monascus anka. Their structures have been elucidated by spectroscopic means and chemical modification, Monankarins A-D exhibited monoamine oxidase (MAO) inhibitory activity, while the activity was not observed in monankarins E and F or some other simple coumarins. Monankarin C (3) showed stronger inhibition of MAO-B than MAO-A in mice brain, However, the specificity was not found in mice liver MAO.