Malignant mixed tumors of the major salivary glands. Special reference to the histologic structure in metastases
Malignant mixed tumors of the major salivary glands. Special reference to the histologic structure in metastases
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主要唾液腺的恶性混合瘤。
DOI：
10.1002/1097-0142(196806)21:6
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发表时间：
1968
期刊：
影响因子：
--
通讯作者：
MD CARL
中科院分区：
文献类型：
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作者：
MD J. GUNNAR MOBERGER;MD CARL
在Radiumhemmet和Karolinska Sjukhuset从1921年到1964年对2211个主要唾液腺肿瘤的调查中，一个初步的重新分类结果是1633个被登记为混合肿瘤，其中34个为恶性肿瘤。在这34例病例中，有11例有转移灶的组织学检查。经过对临床病程的进一步研究和仔细的组织学检查，我们排除了两个病例，一个是由于缺乏明确的恶性肿瘤征象，另一个是由于存在另一种恶性肿瘤的可能性更大。其余9例原发肿瘤具有混合性肿瘤（多形性腺瘤）的特征，而在转移灶中只能观察到不同类型的癌。涎腺肿瘤的转移未见多形性结构。在此研究的基础上，作者质疑是否存在一种符合恶性混合肿瘤定义的肿瘤。术语“多形性腺瘤中的癌症”︁被认为更适合于这种类型的肿瘤。
In a suvery of 2211 tumors of the major salivary glands treated at Radiumhemmet and Karolinska Sjukhuset from 1921 to 1964 a preliminary reclassification resulted in 1633 being registered as mixed tumors, 34 of them as malignant. Material from metastases was available for histologic examination in 11 of these 34 cases. After a further study of the clinical course and careful histologic examination two were excluded—one in view of the lack of definite signs of malignancy and the other because the existence of another type of malignant tumor was more probable. In the remaining nine cases the primary tumor had the characteristics of a mixed tumor (pleomorphic adenoma), whereas only a carcinoma of varying type could be observed in the metastases. No pleomorphic structures were demonstrable in the metastases from any of the tumors of the salivary gland examined. On the basis of this study the authors question the existence of a tumor warranting the denotation of malignant mixed tumor. The term „cancer in pleomorphic adenoma”︁ is suggested as being more adequate for a tumor of this type.