LANGERHANS CELLS IN PARACOCCIDIOIDOMYCOSIS
LANGERHANS CELLS IN PARACOCCIDIOIDOMYCOSIS
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DOI：
10.1001/archderm.123.4.479
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发表时间：
1987-04-01
影响因子：
--
通讯作者：
GIGLI, I
中科院分区：
文献类型：
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作者：
GIMENEZ, MF;TAUSK, F;GIGLI, I
朗格汉斯细胞（LC）似乎在细胞免疫反应低下的疾病中发生了改变。我们测量了播散性副球孢子菌病患者皮肤中 LC 的密度。该研究是使用表皮片的腺苷三磷酸酶染色进行的。对 16 名副球孢子菌病患者进行了评估。与对照组的数量（LC，689±204/mm2）相比，他们的 LC（LC，323±135/mm2）显着减少。在 LC 数量较少的患者中注意到这些细胞的形态学改变。这些发现可能反映了巴西副球孢子菌感染继发的细胞免疫功能低下。
Langerhans'' cells (LCs) appear to be altered in diseases that express a depressed cellular immune response. We measured the density of LCs in the skin of patients with the disseminated form of paracoccidioidomycosis. The study was performed using adenosine triphosphatase staining of epidermal sheets. Sixteen patients with paracoccidioidomycosis were evaluated. They had a highly significant reduction in LCs (LCs, 323 .+-. 135/mm2) when compared with the number (LCs, 689 .+-. 204/mm2) found in the control subjects. Morphological alterations of these cells were noted in patients with low numbers of LCs. These findings may reflect the depressed cellular immunity secondary to the infection with Paracoccidioides brasiliensis.