Photodynamic Therapy for Cancer
Photodynamic Therapy for Cancer
复制标题
DOI：
10.2504/kds.60.1_1
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
T. Inokuchi
中科院分区：
文献类型：
--
作者：
T. Inokuchi
光动力疗法（PDT）是一种用于肿瘤性和非肿瘤性疾病的治疗方法，它利用光敏剂、光和靶组织中的氧所引发的光化学反应。PDT包括给予一种能选择性地在靶组织中积聚的光敏剂，并以特定波长进行激光照射以产生光化学反应。这种光激活会产生单线态氧和其他活性氧物质，它们会对细胞成分造成氧化损伤，引发细胞修复和恢复，或者通过细胞凋亡和/或坏死导致细胞死亡。PDT消除肿瘤的机制包括光毒性作用造成的直接损伤、肿瘤血管的塌陷以及诱导的炎症细胞浸润。
Photodynamic therapy (PDT) is a treatment for both neoplastic and nonneoplastic diseases utilizing photochemical reactions induced by a photosensitizer, light and oxygen in the target tissue, PDT consists of administration of a photosensitizer that selectively accumulates in the target tissue and laser irradiation at a specific wavelength to produce photochemical reactions. This photoactivation produces singlet oxygen and other reactive oxygen species that cause oxidative damage to cellular components, triggering either cellular repair and recovery or cell death by apoptosis and/or necrosis. The mechanisrns of PDT tumor eradication include the direct damage by phototoxic action, collapse of the tumor vasculature, and induced inflammatory cell infiltration and