Percentage of Asymptomatic Infections among SARS-CoV-2 Omicron Variant-Positive Individuals: A Systematic Review and Meta-Analysis.
Percentage of Asymptomatic Infections among SARS-CoV-2 Omicron Variant-Positive Individuals: A Systematic Review and Meta-Analysis.
复制标题
SARS-CoV-2 Omicron变异阳性个体中无症状感染的百分比：系统性综述和荟萃分析。
DOI：
10.3390/vaccines10071049
复制
发表时间：
2022-06-30
期刊：
影响因子：
7.8
通讯作者：
Liu M
中科院分区：
文献类型：
--
作者：
Shang W;Kang L;Cao G;Wang Y;Gao P;Liu J;Liu M
背景资料：无症状感染者是2019冠状病毒病的潜在传播源，特别是在SARS-CoV-2 Omicron变异体流行期间。我们的目的是评估通过基因测序或特异性聚合酶链反应（PCR）检测到的SARS-CoV-2 Omicron变异阳性个体中无症状感染的百分比。方法：我们检索了2021年11月26日至2022年4月13日的PubMed、EMBASE和Web of Science。该荟萃分析按照系统性综述和荟萃分析的首选报告项目指南进行，并在PROSPERO注册（CRD 42022327894）。三名研究人员独立提取数据，两名研究人员使用预先指定的标准评估质量。使用随机效应模型估计SARS-CoV-2 Omicron无症状感染的合并百分比及其95%置信区间（CI）。结果：我们的荟萃分析纳入了8项合格的研究，涵盖了7640例Omicron变异阳性个体和2190例无症状感染者。无症状感染者的合并百分比为32.40%（95%CI：25.30-39.51%），在发展中国家人群中更高（38.93%; 95% CI：19.75-58.11%），疫苗接种率≥ 80%（35.93%; 95%CI：25.36-46.51%），有旅行史（40.05%; 95% CI：7.59-72.51%），社区感染（37.97%; 95% CI：10.07-65.87%），中位年龄< 20岁（43.75%; 95% CI：38.45-49.05%）。结论：在这项系统性综述和荟萃分析中，SARS-CoV-2 Omicron变异体阳性个体中无症状感染的汇总百分比为32.40%。接种疫苗的人，年轻人（中位年龄< 20岁），有旅行史，在临床环境外感染（社区感染）的无症状感染者比例较高。需要进行筛查，以防止Omicron变异无症状感染者导致的聚集性流行或持续社区传播，特别是对于已成功控制SARS-CoV-2的国家和地区。
Background: Asymptomatic infections are potential sources of transmission for coronavirus disease 2019, especially during the epidemic of the SARS-CoV-2 Omicron variant. We aimed to assess the percentage of asymptomatic infections among SARS-CoV-2 Omicron variant-positive individuals detected by gene sequencing or specific polymerase chain reaction (PCR). Methods: We searched PubMed, EMBASE, and Web of Science from 26 November 2021 to 13 April 2022. This meta-analysis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and was registered with PROSPERO (CRD42022327894). Three researchers independently extracted data and two researchers assessed quality using pre-specified criteria. The pooled percentage with 95% confidence interval (CI) of asymptomatic infections of SARS-CoV-2 Omicron was estimated using random-effects models. Results: Our meta-analysis included eight eligible studies, covering 7640 Omicron variant-positive individuals with 2190 asymptomatic infections. The pooled percentage of asymptomatic infections was 32.40% (95% CI: 25.30–39.51%) among SARS-CoV-2 Omicron variant-positive individuals, which was higher in the population in developing countries (38.93%; 95% CI: 19.75–58.11%), with vaccine coverage ≥ 80% (35.93%; 95% CI: 25.36–46.51%), with a travel history (40.05%; 95% CI: 7.59–72.51%), community infection (37.97%; 95% CI: 10.07–65.87%), and with a median age < 20 years (43.75%; 95% CI: 38.45–49.05%). Conclusion: In this systematic review and meta-analysis, the pooled percentage of asymptomatic infections was 32.40% among SARS-CoV-2 Omicron variant-positive individuals. The people who were vaccinated, young (median age < 20 years), had a travel history, and were infected outside of a clinical setting (community infection) had higher percentages of asymptomatic infections. Screening is required to prevent clustered epidemics or sustained community transmission caused by asymptomatic infections of Omicron variants, especially for countries and regions that have successfully controlled SARS-CoV-2.
登录
查看更多内容
影响因子：
4.5
作者：
Kim MK;Lee B;Choi YY;Um J;Lee KS;Sung HK;Kim Y;Park JS;Lee M;Jang HC;Bang JH;Chung KH;Jeon J
通讯作者：
Jeon J
DOI：
10.2807/1560-7917.es.2021.26.50.2101147
发表时间：
2021-12
期刊：
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
影响因子：
--
作者：
Brandal LT;MacDonald E;Veneti L;Ravlo T;Lange H;Naseer U;Feruglio S;Bragstad K;Hungnes O;Ødeskaug LE;Hagen F;Hanch-Hansen KE;Lind A;Watle SV;Taxt AM;Johansen M;Vold L;Aavitsland P;Nygård K;Madslien EH
通讯作者：
Madslien EH
影响因子：
4.5
作者：
Lee JJ;Choe YJ;Jeong H;Kim M;Kim S;Yoo H;Park K;Kim C;Choi S;Sim J;Park Y;Huh IS;Hong G;Kim MY;Song JS;Lee J;Kim EJ;Rhee JE;Kim IH;Gwack J;Kim J;Jeon JH;Lee WG;Jeong S;Kim J;Bae B;Kim JE;Kim H;Lee HY;Lee SE;Kim JM;Park H;Yu M;Choi J;Kim J;Lee H;Jang EJ;Lim D;Lee S;Park YJ
通讯作者：
Park YJ
影响因子：
33.9
作者：
Fowlkes, Ashley L.;Yoon, Sarang K.;Gaglani, Manjusha
通讯作者：
Gaglani, Manjusha
2021年11月，中国香港隔离酒店的SARS-COV-2 OMICRON变体的可能传播。
影响因子：
11.8
作者：
Gu H;Krishnan P;Ng DYM;Chang LDJ;Liu GYZ;Cheng SSM;Hui MMY;Fan MCY;Wan JHL;Lau LHK;Cowling BJ;Peiris M;Poon LLM
通讯作者：
Poon LLM