Advanced ovarian cancer: a prospective randomised trial of chlorambucil versus combined cyclophosphamide and cis-diamminedichloroplatinum.
Advanced ovarian cancer: a prospective randomised trial of chlorambucil versus combined cyclophosphamide and cis-diamminedichloroplatinum.
复制标题
晚期卵巢癌：苯丁酸氮芥与环磷酰胺和顺式二氯二氨合用的前瞻性随机试验。
DOI：
--
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
M. Tattersall
中科院分区：
文献类型：
--
作者：
D. Bell;R. Woods;J. Levi;R. Fox;M. Tattersall
一项前瞻性随机试验对 37 名晚期卵巢癌患者进行了治疗，比较了苯丁酸氮芥与环磷酰胺和顺式二氯铂 (顺式 DDP) 的组合。联合治疗与总体缓解率提高相关（69% 对比 23%）（p = 0.04）。缓解与较长的中位生存期相关，但接受环磷酰胺/顺式 DDP 的患者没有显示出生存优势。需要进行更大规模的研究来充分评估含有顺式 DDP 的治疗方案在晚期卵巢癌治疗中的潜力。
Thirty-seven patients with advanced ovarian cancer were treated in a prospective, randomised trial comparing chlorambucil with a combination of cyclophosphamide and cis-diamminedichloroplatinum (cis DDP). Treatment with the combination was associated with an increased overall response rate (69% versus 23%) (p = 0.04). A response was associated with a longer median survival but no survival advantage was demonstrated for patients who received cyclophosphamide/cis DDP. A larger study is needed to evaluate fully the potential of regimens containing cis DDP in the management of advanced ovarian cancer.