Reference intervals of spinal mobility measures in normal individuals: the mobility study
Reference intervals of spinal mobility measures in normal individuals: the mobility study
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DOI：
10.1136/annrheumdis-2013-204953
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发表时间：
2015-06-01
影响因子：
27.4
通讯作者：
Landewe, Robert
中科院分区：
文献类型：
--
作者：
Ramiro, Sofia;van Tubergen, Astrid;Landewe, Robert
目的 建立中轴型脊柱关节炎患者推荐的脊柱活动度测量参考区间 (RI)，并确定正常人年龄、身高和性别对脊柱活动度的影响。 方法 在 20-69 岁的正常人中进行横断面研究 (MOBILITY)。招募按性别、年龄（10岁类别）和身高（10厘米类别）进行分层。评估了十一项脊柱活动度指标。每个测量值均得出特定年龄的 RI 和百分位数。结果 包括 393 名志愿者。所有脊柱活动度指标均随着年龄的增长而下降。因此，开发了针对年龄的 RI。显示了每个脊柱活动度测量值和不同年龄的 95% RI（第 2.5 个和 97.5 个百分位数）以及第 5、10、25、50、75 和 90 个百分位数。还为每个测量绘制了流动性百分位曲线。例如，25岁受试者的脊柱侧屈的95%RI为16.2-28.0cm，45岁受试者的95%RI为13.2-25.0cm，65岁受试者的95%RI为10.1-21.9cm。调整年龄后，不需要特定性别的 RI，而某些测量值的 RI 需要根据身高进行调整。结论 对于正常人的每项脊柱活动度测量，得出了年龄特定的 RI 和百分位数。这些可以指导临床医生评估中轴型脊柱关节炎患者的活动能力。 RI 可作为正常与异常的临界水平，而活动百分位数曲线可用于评估中轴型脊柱关节炎患者的活动水平。
Objectives To establish reference intervals (RIs) for spinal mobility measures as recommended for patients with axial spondyloarthritis, and to determine the effect of age, height and gender on spinal mobility, in normal individuals.Methods A cross-sectional study (MOBILITY) was conducted among normal individuals aged 20-69years. Recruitment was stratified by gender, age (10-year categories) and height (10cm categories). Eleven spinal mobility measures were assessed. Age specific RIs and percentiles were derived for each measure.Results 393 volunteers were included. All spinal mobility measures decreased with increasing age. Therefore, age specific RIs were developed. The 95% RIs (2.5th and 97.5th percentiles), as well as the 5th, 10th, 25th, 50th, 75th and 90th percentiles for each spinal mobility measure and different ages are presented. Mobility percentile curves were also plotted for each of the measures. For instance, the 95% RI for lateral spinal flexion was 16.2-28.0cm for a 25-year-old subject, 13.2-25.0cm for a 45-year-old subject and 10.1-21.9cm for a 65-year-old subject. After adjustment for age, there was no need for gender specific RIs, while RIs of some measures are height-adjusted.Conclusions Age specific RIs and percentiles were derived for each of the spinal mobility measures for normal individuals. These may guide clinicians when assessing the mobility of patients with axial spondyloarthritis. The RIs may serve as cut-off levels for normal' versus abnormal', whereas the mobility percentile curves may be used to assess the level of mobility of patients with axial spondyloarthritis.