Depression and Elevated Inflammation Among Chinese Older Adults: Eight Years After the 2003 SARS Epidemic
Depression and Elevated Inflammation Among Chinese Older Adults: Eight Years After the 2003 SARS Epidemic
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DOI：
10.1093/geront/gnaa219
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发表时间：
2021-02-18
期刊：
影响因子：
5.7
通讯作者：
Burr, Jeffrey A.
中科院分区：
文献类型：
--
作者：
Wang, Haowei;Stokes, Jeffrey E.;Burr, Jeffrey A.
背景和目标：本研究调查了2003年严重急性呼吸系统综合征（SARS）疫情暴露与危机后8年中国老年人抑郁和炎症之间的关系。研究设计和方法：数据来自2011年中国健康与养老纵向调查，包括N = 4，341名60岁及以上的中国成年人。在调查中，当地官员确定了2003年SARS爆发是否是他们社区历史上的重大灾难之一。抑郁症进行了评估，流行病学中心抑郁量表和炎症的C-反应蛋白（CRP）收集的参与者通过静脉血draws.Results：结果从多层次Logistic回归模型显示，中国老年人生活在社区暴露于SARS更有可能有升高的CRP相比，那些不生活在这样的社区。此外，社区SARS暴露与中国老年人谁没有感知的社会支持抑郁症的风险更大。在中国老年人谁有低水平的社会参与，社区SARS暴露更密切相关的升高CRP.Discussion and Implications：研究结果表明，社区一级暴露于SARS疫情对中国老年人的健康产生了持久的后果。然而，积极的社会参与和支持性的社会关系提供了重要的资源，可以缓冲接触SARS流行病的负面影响。
Background and Objectives: This study examined associations between exposure to the 2003 Severe Acute Respiratory Syndrome (SARS) epidemic and Chinese older adults' depression and inflammation 8 years after the crisis. Further, this study investigated the buffering effects of perceived social support and social participation.Research Design and Methods: Data were drawn from the 2011 China Health and Retirement Longitudinal Survey, including N = 4,341 Chinese adults aged 60 years and older. For the survey, local officials identified whether the 2003 SARS outbreak was one of the major disasters in the history of their communities. Depression was assessed by the Center for Epidemiological Studies-Depression scale and inflammation was measured by C-reactive protein (CRP) collected from participants via venous blood draws.Results: Results from multilevel logistic regression models revealed that Chinese older adults living in communities exposed to SARS were more likely to have elevated CRP compared to those not living in such communities. Moreover, community SARS exposure was associated with greater risks of depression for Chinese older adults who had no perceived social support. Among Chinese older adults who had low levels of social participation, community SARS exposure was more strongly related to elevated CRP.Discussion and Implications: Findings suggest community-level exposure to the SARS epidemic had enduring consequences for Chinese older adults' health. However, active social participation and supportive social ties provided important resources that may buffer against negative effects of exposure to the SARS epidemic.