Loss of PTEN expression as a prognostic marker for tongue cancer
Loss of PTEN expression as a prognostic marker for tongue cancer
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DOI：
10.1001/archotol.127.12.1441
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发表时间：
2001-12-01
影响因子：
--
通讯作者：
Mao, L
中科院分区：
文献类型：
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作者：
Lee, JI;Soria, JC;Mao, L
背景资料：目的：探讨舌鳞状细胞癌中PTEN蛋白的表达及其临床意义。设计：回顾性分析原发性口腔舌鳞癌标本中PTEN蛋白的表达。地点：学术中心，患者和方法：通过免疫组化分析，在41例II、III和IV期舌鳞状细胞癌患者的组织样本中测定了PTEN表达。所有患者均接受了根治性手术治疗，中位随访时间为81个月。生存分析采用Kaplan-Meier法。多因素分析采用考克斯比例风险模型。结果：41例肿瘤中12例（29%）PTEN蛋白表达缺失。肿瘤缺乏PTEN表达的患者的总生存时间（P= 0.03）和无事件生存时间（P= 0.01）明显短于PTEN阳性表达的患者。多变量回归分析表明，PTEN表达是一个独立的预测结果不佳时，肿瘤分期和nodal status.Conclusions：虽然PTEN基因的遗传变异是罕见的头颈部鳞状细胞癌，损失的PTEN是不是一个罕见的事件，在鳞状细胞癌的舌头。PTEN表达的缺乏可能是这种肿瘤类型患者临床结局的独立预后指标。
Background: Abnormalities of PTEN, a candidate tumor suppressor gene located at 10q23.3, play an important role in the tumorigenesis of multiple tumor types.Objectives: To investigate the expression of PTEN and its clinical implication in squamous cell carcinoma of the tongue.Design: Retrospective analysis of PTEN protein expression in archived primary oral tongue tumor samples.Setting: Academic center,Patients and Methods: PTEN expression was determined by immunohistochemical analysis in tissue samples from 41 patients with stage II, III, and IV squamous cell carcinoma of the tongue. All the patients underwent curative surgical treatment with a median follow-up of 81 months. The Kaplan-Meier method was used for survival analysis. Multivariate analysis was performed according to the Cox proportional hazards model.Results: Lack of staining for PTEN was demonstrated in 12 (29%) of the 41 tumors. Patients whose tumors lacked PTEN expression had a significantly shorter overall survival time (P=.03) and event-free survival time (P=.01) than those patients with positive PTEN expression. Multivariate regression analysis demonstrated that PTEN expression is an independent predictor of poor outcome when compared with tumor stage and nodal status.Conclusions: Although genetic alterations of the PTEN gene are rare in head and neck squamous cell carcinoma, loss of PTEN is not an uncommon event in squamous cell carcinoma of the tongue. Lack of PTEN expression may be an independent prognostic indicator for clinical outcome in patients with this tumor type.