Circadian molecular clockworks in non-model insects
Circadian molecular clockworks in non-model insects
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DOI：
10.1016/j.cois.2014.12.006
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发表时间：
2015-02-01
影响因子：
5.3
通讯作者：
Matsumoto, Akira
中科院分区：
文献类型：
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作者：
Tomioka, Kenji;Matsumoto, Akira
近年来分子遗传技术的发展正在推动对多种非模式昆虫生物钟机制的研究，揭示其分子钟机制的多样性和共性。与果蝇一样，它们的时钟通常由时钟基因组成，包括 period、timeless、Clock 和 Cycle，但膜翅目物种除外，其基因组中缺乏 timeless。然而，与果蝇不同的是，一些昆虫表现出类似脊椎动物的特征：时钟机制涉及哺乳动物型隐花色素，周期是有节奏地表达的，而时钟是组成型表达的。尽管大多数昆虫的生物钟振荡机制仍有待研究，但 RNAi 和基因组编辑技术应该会加速研究进程，从而了解可变的明显行为节律的起源，例如夜间、白天和黄昏活动节律。
The recent development of molecular genetic technology is promoting studies on the clock mechanism of various non-model insect species, revealing diversity and commonality of their molecular clock machinery. Like in Drosophila, their clocks generally consist of clock genes including period, timeless, Clock, and cycle, except for hymenopteran species which lack timeless in their genome. Unlike in Drosophila, however, some insects show vertebrate-like traits: The clock machinery involves mammalian type cryptochrome, cycle is rhythmically expressed, and Clock is constitutively expressed. Although the oscillatory mechanisms of the clock are still to be investigated in most insects, RNAi and genome editing technology should accelerate the study, leading toward understanding the origin of variable overt behavioral rhythms such as nocturnal, diurnal, and crepuscular activity rhythms.