A plausible two-state model for cytochrome c oxidase.
A plausible two-state model for cytochrome c oxidase.
复制标题
细胞色素 c 氧化酶的合理两态模型。
DOI：
10.1073/pnas.78.11.7115
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发表时间：
1981
影响因子：
11.1
通讯作者：
J. Wyman
中科院分区：
文献类型：
--
作者：
M. Wilson;J. Peterson;E. Antonini;M. Brunori;A. Colosimo;J. Wyman
成功地描述了脉冲和静止细胞色素c氧化酶(铁细胞色素c：氧氧化还原酶，EC 1.9.3.1)的催化性质，用最小动力学方案表示，并用数值计算进行了模拟。一个两态模型解释了细胞色素C氧化酶在周转过程中的激活，其中每种构象中存在的酶的相对数量由一侧的电子通量和O2结合速率以及另一侧的相互转化率来调节。
The catalytic properties of pulsed and resting cytochrome c oxidase (ferrocytochrome c: oxygen oxidoreductase, EC 1.9.3.1), expressed in terms of a minimal kinetic scheme and simulated by numerical computations, were successfully described. A two-state model, in which the relative amounts of the enzyme present in each conformation are regulated by the rates of electron flux and O2 binding on one side and the interconversion rates on the other, accounts for the activation of cytochrome c oxidase during turnover.