IMMUNITY IN HUMANS TO NECATOR-AMERICANUS - IGE, PARASITE WEIGHT AND FECUNDITY
IMMUNITY IN HUMANS TO NECATOR-AMERICANUS - IGE, PARASITE WEIGHT AND FECUNDITY
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DOI：
10.1111/j.1365-3024.1995.tb00968.x
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发表时间：
1995-02-01
影响因子：
2.2
通讯作者：
WALSH, EA
中科院分区：
文献类型：
--
作者：
PRITCHARD, DI;QUINNELL, RJ;WALSH, EA
在一个地方性感染的人群中研究了体液免疫应答对美洲钩虫体重和繁殖力的影响。总IgE水平和寄生虫的重量和繁殖力之间有一个非常显着的负相关性，在控制任何主机的年龄和钩虫负担的影响。这种相关性在初始治疗和2年后的再感染中均存在。在初始治疗时，嗜酸性粒细胞数量与钩虫体重和生殖力之间存在类似的负相关性。与N. americanus排泄分泌产物较弱，不显着，虽然有一个趋势，与抗ES IgE呈负相关。这是第一个现场证据表明，有效的人体免疫反应，以N。美国人虽然这种作用的机制尚不清楚，我们认为，总IgE水平反映了Th2细胞活化的水平。
The effect of the humoral immune response on the weight and fecundity of the hookworm Necator americanus was examined in an endemically-infected human population. There was a highly significant negative correlation between total IgE levels and parasite weight and fecundity, after controlling for any effects of host age and hookworm burden. This correlation was present both at initial treatment and after 2 years' reinfection. There was a similar negative correlation between the number of eosinophils and hookworm weight and fecundity at initial treatment. Correlations with levels of specific antibodies to N. americanus excretory-secretory products were weaker and not significant, although there was a trend towards negative correlations with anti-ES IgE. This is the first field evidence for an effective human immune response to N. americanus. Although the mechanism of this effect is not clear, we suggest that total IgE levels reflected the level of Th2 cell activation.