Associations of first trimester co-use of tobacco and Cannabis with prenatal immune response and psychosocial well-being
Associations of first trimester co-use of tobacco and Cannabis with prenatal immune response and psychosocial well-being
复制标题
DOI：
10.1016/j.ntt.2019.03.002
复制
发表时间：
2019-05-01
影响因子：
2.9
通讯作者：
Lile, Josh
中科院分区：
文献类型：
--
作者：
Ashford, Kristin;Fallin-Bennett, Amanda;Lile, Josh
目的：本研究旨在描述孕早期烟草和大麻共同使用与母体免疫反应和心理社会健康的关系，相对于仅使用烟草。方法：初步中点分析包括138名经生物学验证使用烟草的孕妇，其中38人（28%）最近也检测出大麻使用阳性。收集了母亲感知压力（感知压力量表）、抑郁症状（爱丁堡产后抑郁量表）和血清免疫标志物（IL-1 β、IL-2、IL-6、IL-8、IL-10、TNF α、CRP、MMP8），尽管细胞因子数据仅适用于122名妇女。结果：参与者的平均年龄为29.1岁，大约一半的人受过高中教育或更低，一半的人失业。与只吸烟的人相比，共同吸烟者更有可能是非白人、更年轻、经济状况更差。在调整后的线性回归模型中，在调整了年龄、种族/民族、体重指数和烟草使用群体（烟草卷烟、电子尼古丁传递装置[ENDS]或两者）后，共同使用者的tnf - α水平明显低于仅烟草使用者。tnf - α是该分析中发现的唯一显著的免疫标记物。所有参与者的测量压力水平（M = 5.9, SD = 3.3；电位范围0-16）和抑郁评分（M = 7.8, SD = 5.8；电位范围0-30）都很低，并且随着共同使用而没有差异。结论：初步结果表明，在妊娠前三个月共同使用的妇女在8个标志物中的一个上表现出促炎免疫反应性下降。需要进一步的研究来确定这种免疫调节对胎儿健康结果的影响以及大麻的独特贡献。
Purpose: This study aims to describe the association of first trimester co-use of tobacco and cannabis with maternal immune response and psychosocial well-being, relative to tobacco use only.Methods: A preliminary midpoint analysis included 138 pregnant women with biologically verified tobacco use, 38 of whom (28%) also tested positive for recent cannabis use. Maternal perceived stress (Perceived Stress Scale), depressive symptoms (Edinburgh Postnatal Depression Scale), and serum immune markers (IL-1 beta, IL-2, IL-6, IL-8, IL-10, TNF alpha, CRP, MMP8), were collected, although cytokine data were only available for 122 women.Results: Participant average age was 29.1 years, approximately half had a high school education or less, and half were unemployed. Compared to tobacco only users, co-users were more likely to be non-White, younger and more economically disadvantaged. In the adjusted linear regression models, TNF-alpha levels were significantly lower among co-users relative to tobacco only users, after adjusting for age, race/ethnicity, body mass index and tobacco use group (tobacco cigarettes, electronic nicotine delivery devices [ENDS] or both). TNF-alpha was the only immune marker found to be significant in this analysis. Measured stress levels (M = 5.9, SD = 3.3; potential range 0-16) and depression scores (M = 7.8, SD = 5.8; potential range 0-30) were low across all participants and did not differ as a function of co-use.Conclusion: Preliminary results suggest women co-using during the first trimester exhibit decreased pro-inflammatory immune responsivity on one out of eight markers. Further research is needed to determine the impact of this immune modulation on fetal health outcomes and the unique contribution of cannabis.