Prevalence of Symptoms More Than Seven Months After Diagnosis of Symptomatic COVID-19 in an Outpatient Setting
Prevalence of Symptoms More Than Seven Months After Diagnosis of Symptomatic COVID-19 in an Outpatient Setting
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DOI：
10.7326/m21-0878
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发表时间：
2021-09-01
影响因子：
39.2
通讯作者：
Guessous, Idris
中科院分区：
文献类型：
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作者：
Nehme, Mayssam;Braillard, Olivia;Guessous, Idris
背景资料：随着全球数百万SARS-CoV-2感染者的出现，越来越多的患者出现了持续数周至数月的长期临床影响。目的：描述COVID-19诊断后7至9个月的症状。设计：自报调查和半结构化电话访谈在入组时和诊断后30至45天和7至9个月。设置：2020年3月18日至5月15日，对在日内瓦大学医院检测出SARS-CoV-2呈阳性的有症状者进行了虚拟临床门诊随访计划CoviCare的随访。在确诊后30至45天和7至9个月再次联系患者。参与者：2020年3月18日至5月15日期间参与CoviCare计划的人员。测量：对符合COVID-19的症状进行标准化访谈，并进行强度分级。结果：在完成基线访谈的629名研究参与者中，410人在COVID-19诊断后7至9个月完成了随访; 39.0%的人报告了残留症状。疲劳（20.7%）是最常见的症状，其次是味觉或嗅觉丧失（16.8%），呼吸困难（11.7%）和头痛（10.0%.Limitation：局限性包括概括性和缺失数据为34.8%的participants.Conclusion：SARS-CoV-2感染后的残留症状是常见的，否则年轻和健康的人在门诊设置。这些发现有助于认识到这种疾病的长期影响，迄今为止，这种疾病主要是通过促进SARS-CoV-2急性后后遗症的交流，并鼓励医生继续对患者进行长期监测来计算的。
Background: With millions of SARS-CoV-2 infections worldwide, increasing numbers of patients are coming forward with long-term clinical effects of the disease lasting several weeks to months.Objective: To characterize symptoms 7 to 9 months after diagnosis of COVID-19.Design: Self-reported surveys and semistructured telephone interviews at enrollment and 30 to 45 days and 7 to 9 months from diagnosis.Setting: From 18 March to 15 May 2020, symptomatic persons who tested positive for SARS-CoV-2 at the Geneva University Hospitals were followed by CoviCare, a virtual, clinical, outpatient follow-up program. Persons were contacted again at 30 to 45 days and 7 to 9 months from diagnosis.Participants: Persons who were a part of the CoviCare program from 18 March to 15 May 2020.Measurements: A standardized interview of symptoms consistent with COVID-19, with grading of intensity.Results: Of the 629 participants in the study who completed the baseline interviews, 410 completed follow-up at 7 to 9 months after COVID-19 diagnosis; 39.0% reported residual symptoms. Fatigue (20.7%) was the most common symptom reported, followed by loss of taste or smell (16.8%), dyspnea (11.7%), and headache (10.0%).Limitation: Limitations include generalizability and missing data for 34.8% of participants.Conclusion: Residual symptoms after SARS-CoV-2 infection are common among otherwise young and healthy persons followed in an outpatient setting. These findings contribute to the recognition of long-term effects in a disease mostly counted by its death toll to date by promoting communication on postacute sequelae of SARS-CoV-2 and encouraging physicians to continue long-term monitoring of their patients.