Extraction of anti-cancer damnacanthal from roots of Morinda citrifolia by subcritical water
Extraction of anti-cancer damnacanthal from roots of Morinda citrifolia by subcritical water
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DOI：
10.1016/j.seppur.2007.01.004
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发表时间：
2007-07-01
影响因子：
8.6
通讯作者：
Shotipruk, Artiwan
中科院分区：
文献类型：
--
作者：
Anekpankul, Thitiporn;Goto, Motonobu;Shotipruk, Artiwan
巴戟天的根是重要化合物蒽醌的来源，蒽醌已被证明具有抗病毒作用。抗菌、抗癌活性。在这种植物的根部最有药用价值的蒽醌是damnacanthal，它已被用于治疗慢性疾病，如癌症和心脏病。在这项研究中，亚临界水提取作为一个良性的替代溶剂提取的damnacanthal从巴戟天大溪地干根进行了研究。实验在连续流动系统中进行，压力为4 MPa，温度为150 ~ 220摄氏度，水流速为1.6、2.4、3.2和4 ml/min。采用反相高效液相色谱法（RP-HPLC）和紫外检测器（250 nm）对虎刺醛进行定量分析。研究结果表明，在170 ℃下获得了用亚临界水提取的最高量的虎刺醛。除了温度的影响，在不同的流速下进行萃取，并用数学模型拟合数据，以确定萃取机理。结果表明，整个萃取机理受溶质分配平衡和液膜外部传质的影响。然而，解吸模型可以合理地描述巴戟天在高流速下的提取行为。(c)2007 Elsevier B. V.保留所有权利。
Roots of Morinda citrifolia (Noni or Yor in Thai) are the source of important compounds, anthraquinones, which have been proven to have anti-viral. anti-bacterial, anti-cancer activities. The most medicinally valuable anthraquinones in the roots of this plant is damnacanthal, which has been used for treatment of chronic diseases such as cancer and heart disease. In this study, subcrifical water extraction was investigated as a benign alternative for solvent extraction of damnacanthal from the dried root of Morinda citrifolia. The experiments were conducted in a continuous flow system at a pressure of 4 MPa at different temperature between 150 and 220 degrees C and water flow rates of 1.6, 2.4, 3.2 and 4 ml/min. The quantitative analysis of damnacanthal was performed using RP-HPLC with UV detection at 250 nm. The results of the study revealed that the highest amount of damnacanthal extracted with subcritical water was obtained at 170 degrees C. In addition to the effect of temperature, extractions were conducted at various flow rates and the data were fitted with mathematic models to determine the extraction mechanism. The results suggested that the overall extraction mechanism was influenced by solute partitioning equilibrium with external mass transfer through liquid film. Nevertheless, the desorption model could describe the extraction behavior of Morinda citrifolia reasonably at high flow rates. (c) 2007 Elsevier B.V. All rights reserved.