Waiting times for radiotherapy: consequences of volume increase for the TCP in oropharyngeal carcinoma
Waiting times for radiotherapy: consequences of volume increase for the TCP in oropharyngeal carcinoma
复制标题
DOI：
10.1016/s0167-8140(03)00036-7
复制
发表时间：
2003-03-01
影响因子：
5.7
通讯作者：
Lagendijk, JJW
中科院分区：
文献类型：
--
作者：
Waaijer, A;Terhaard, CHJ;Lagendijk, JJW
背景和目的：过去几年，放射治疗的等候名单变得越来越长。除了给患者带来心理困扰外，我们还担心等待期间肿瘤的生长，这可能会恶化预后。这项初步研究的目的是调查等待时间内肿瘤的生长情况，并了解其对口咽癌患者的临床后果。应用肿瘤控制概率 (TCP) 模型来评估结果后果。方法和材料：通过在诊断和治疗计划 CT 扫描上勾画出肿瘤轮廓，测量 13 名口咽癌患者的肿瘤体积增加情况。等待时间定义为组织病理学诊断和放射治疗开始之间的时间。对于每个肿瘤，我们计算了肿瘤体积的增加和结果倍增时间。在不延迟治疗的情况下计算每个肿瘤的 TCP 潜在增加。结果：肿瘤体积的平均增加为 70%。平均等待时间为 56 天。包含延迟的预期 TCP 为 47%，如果没有延迟，则可能为 63-66%。 结论：这项研究显示口咽癌在诊断 CT 扫描和治疗计划 CT 扫描之间的时间内肿瘤进展。由于等待时间导致肿瘤体积增加，在放疗前的总等待时间内，这些肿瘤的平均控制损失可能为 16-19%。 (C) 2003 Elsevier Science Ireland Ltd. 保留所有权利。
Background and purpose: Waiting lists for radiotherapy have become longer over the past years. Apart from the psychological distress for the patient we are concerned about tumour growth during this waiting time, which may worsen prognosis. The purpose of this pilot study was to investigate tumour growth in the waiting time and to obtain an indication of its clinical consequences for patients with oropharyngeal carcinoma. A tumour control probability (TCP) model was applied to evaluate consequences for outcome.Methods and materials: Increase in tumour volume was measured for 13 patients with oropharyngeal carcinoma by outlining the tumour on the diagnostic as well as on the treatment planning CT scan. Waiting time was defined as time between histopathological diagnosis and start of radiotherapy. For each tumour we calculated the increase in tumour volume and the turnout doubling time. The potential increase in TCP was calculated for each tumour for the situation without treatment delay.Results: The mean increase in tumour volume was 70%. The mean waiting time was 56 days. Expected TCP with incorporation of delay was 47%, without delay it might have been 63-66%.Conclusion: This study shows tumour progression during the time between the diagnostic CT scan and the treatment planning CT scan in oropharyngeal cancer. As a consequence of waiting time, which allows tumour volume increase, there may be an average control loss of 16-19% for these tumours during the total waiting time before radiotherapy. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.