Subacute exposure to bisphenol F diglycidyl-ether induces chronic dermatitis characterized by psoriasis-like skin inflammation in mice.
Subacute exposure to bisphenol F diglycidyl-ether induces chronic dermatitis characterized by psoriasis-like skin inflammation in mice.
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亚急性接触双酚 F 二缩水甘油醚会诱发小鼠慢性皮炎，其特征为银屑病样皮肤炎症。
DOI：
10.1111/gtc.12995
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Tsuji M
中科院分区：
文献类型：
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作者：
Kitagawa K;Shibata E;Yamamoto M;Harada H;Yoshino K;Iwashita T;Oshima M;Tsuji M
双酚F二缩水甘油醚（BFDGE）广泛应用于塑料制品的合成过程中。据报道，接触与 BFDGE 结构相似且用途相同的双酚 A 二缩水甘油醚 (BADGE) 会导致健康风险，但有关 BFDGE 的信息仍然很少。由于估计产业工人会接触大量的 BFDGE，因此需要澄清与 BFDGE 接触相关的健康风险。我们使用体外评估系统和小鼠暴露模型研究了皮肤暴露于 BFDGE 的毒性。 BFDGE 的致瘤潜力通过 Bhas 42 细胞转化试验得到证实，表明 BFDGE 在体外具有启动子和引发子活性。单次皮肤应用 BFDGE 与轻微的接触过敏症状相关。相比之下，皮肤反复暴露于 BFDGE 2 周会诱发持续性急性炎症，其特征与人类牛皮癣的炎症相似。这是第一份评估 BFDGE 对动物毒性的报告，我们发现 BFDGE 具有诱发皮肤皮炎的健康风险，与人类牛皮癣类似，且与暴露时间相关。
Bisphenol F diglycidyl ether (BFDGE) is widely used in the synthesis process of plastic products. While exposure to bisphenol A diglycidyl ether (BADGE), which has a similar structure to BFDGE and which is used for the same purpose, has been reported to cause health risks, there is still little information on BFDGE. Because it is estimated that the industrial workers are exposed to large amounts of BFDGE, the health risks associated with BFDGE exposure need to be clarified. We investigated the toxicity of cutaneous exposure to BFDGE using an in vitro evaluation system and a mouse exposure model. The tumorigenic potential of BFDGE was confirmed by the Bhas 42 cell transformation assay, which showed that BFDGE has both promoter and initiator activity, in vitro. A single dermal application of BFDGE was associated with minor contact hypersensitivity symptoms. In contrast, repeated dermal exposure to BFDGE for 2 weeks induced persistent acute inflammation with features similar to inflammation in human psoriasis. This is the first report evaluating the toxicity of BFDGE in animals, and we showed that BFDGE carries a health risk of inducing skin dermatitis similar to that in human psoriasis in an exposure period‐dependent manner.