IRON THERAPY IN CHRONICALLY FATIGUED, NONANEMIC WOMEN - DOUBLE-BLIND STUDY
IRON THERAPY IN CHRONICALLY FATIGUED, NONANEMIC WOMEN - DOUBLE-BLIND STUDY
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DOI：
10.7326/0003-4819-52-2-378
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发表时间：
1960-01-01
影响因子：
39.2
通讯作者：
GURNEY, CW
中科院分区：
文献类型：
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作者：
BEUTLER, E;LARSH, SE;GURNEY, CW
铁和安慰剂被给予一组女性谁抱怨慢性疲劳，但其血液血红蛋白水平高于12.0克%。每名妇女接受一个时期的铁治疗和一个时期的安慰剂治疗;铁和安慰剂的介绍顺序随机变化。两个治疗期的相对改善与独立测定的体内铁储存量相关，即，骨髓铁和血浆铁及铁结合能力。每隔一段时间进行血红蛋白测定。虽然在研究开始时患者的血红蛋白值均在正常范围内，但当给予Fe时，Fe缺乏组的平均血红蛋白水平增加。显然，虽然这些患者的血红蛋白值在正常范围内，但经常低于他们的个人标准。在安慰剂给药期间，具有足够铁储存的患者组或铁缺乏组的平均血红蛋白水平未发生显著变化。在18例铁缺乏患者中，13例铁治疗比安慰剂治疗表现出更多的症状改善，而5例安慰剂治疗比铁治疗改善更多。相比之下，11名妇女只有轻微减少铁储存或正常铁储存，4改善更多的铁，5表现出更多的改善与安慰剂和2没有改善。鉴于这些结果，非贫血妇女可能从铁治疗中获益的可能性值得进一步研究。
Iron and placebo were given to a group of women who complained of chronic fatigue but whose blood hemoglobin levels were above 12.0 g%. Each woman received one period of Fe therapy and one period of placebo therapy; the order of presentation of Fe and placebo was varied at random. Comparative improvement in the 2 periods of therapy was correlated with independently determined measures of the body Fe stores, viz., bone marrow stainable Fe and plasma Fe and Fe-binding capacity. Hemoglobin determinations were carried out at intervals. Although the hemoglobin values of the patients were all within the normal range at the beginning of the study, an increase in the average hemoglobin level occurred in the Fe-deficient group when they were given Fe. Apparently, although the hemoglobin value of these patients was within the normal range, it was frequently below their individual norm. No significant change in the average hemoglobin level occurred in the group of patients with adequate Fe stores, or in the Fe-deficient group, during placebo administration. Of 18 Fe-depleted patients, 13 manifested more symptomatic improvement with Fe therapy than with placebo therapy, while 5 improved more with placebo therapy than with Fe therapy. In contrast, of 11 women with only slightly reduced Fe stores or normal Fe stores, 4 improved more with Fe, 5 manifested more improvement with placebo and 2 did not improve at all. In view of these results, the possibility that nonanemic women may benefit clinically from Fe therapy deserves further study.