An evolutionary gap in primate default mode network organization.

An evolutionary gap in primate default mode network organization.
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DOI:
10.1016/j.celrep.2022.110669
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发表时间:
2022-04-12
期刊:
影响因子:
8.8
通讯作者:
Constantinidis, Christos
Constantinidis, Christos
中科院分区:
生物学1区
文献类型:
--
作者:
Garin, Clement M.;Hori, Yuki;Everling, Stefan;Whitlow, Christopher T.;Calabro, Finnegan J.;Luna, Beatriz;Froesel, Mathilda;Gacoin, Maeva;Ben Hamed, Suliann;Dhenain, Marc;Constantinidis, Christos

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人类默认模式网络(DMN)在休息和认知状态(如自我导向的想法)时参与。灵长类动物中相互连接的同源皮层区域构成了一个网络,被认为是等价的。在这里,基于人类和非类人灵长类动物(猕猴,绒猴,和鼠狐猴)之间的DMN的跨物种比较,我们报告的连接配置文件的主要差异。最重要的是,非类人灵长类动物的内侧前额叶皮质(mPFC)与后扣带回皮质(PCC)的联系很差,尽管人类PCC和mPFC之间的强相关活动是人类DMN的一个关键特征。相反,一个额颞叶静息状态网络,涉及mPFC检测到一致的非类人猿灵长类动物物种。这些共同的功能特征之间共享的非类人猿灵长类动物,但不与人类表明灵长类动物的DMN及其相关的认知功能的组织中的实质性差距。通过比较人类、猕猴、绒猴和鼠狐猴的静息态网络,加林等人在非类人灵长类动物中发现了两个包含人类默认模式网络同源区域的网络。mPFC和PCC在人类DMN中紧密连接,但在非类人灵长类动物中彼此连接较差。
The human default mode network (DMN) is engaged at rest and in cognitive states such as self-directed thoughts. Interconnected homologous cortical areas in primates constitute a network considered as the equivalent. Here, based on a cross-species comparison of the DMN between humans and non-hominoid primates (macaques, marmosets, and mouse lemurs), we report major dissimilarities in connectivity profiles. Most importantly, the medial prefrontal cortex (mPFC) of non-hominoid primates is poorly engaged with the posterior cingulate cortex (PCC), though strong correlated activity between the human PCC and the mPFC is a key feature of the human DMN. Instead, a fronto-temporal resting-state network involving the mPFC was detected consistently across non-hominoid primate species. These common functional features shared between non-hominoid primates but not with humans suggest a substantial gap in the organization of the primate’s DMN and its associated cognitive functions. By comparing resting-state networks in humans, macaques, marmosets, and mouse lemurs, Garin et al. identify two networks in non-hominoid primates that include homolog areas of the human default mode network. The mPFC and PCC are tightly connected in the human DMN but poorly connected to each other across non-hominoid primates.
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