Is nuclear factor kappa-B the missing link between inflammation, cancer and alteration in hepatic drug metabolism in patients with cancer?
Is nuclear factor kappa-B the missing link between inflammation, cancer and alteration in hepatic drug metabolism in patients with cancer?
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DOI：
10.1016/j.ejca.2006.01.005
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发表时间：
2006-04-01
影响因子：
8.4
通讯作者：
Pascussi, JM
中科院分区：
文献类型：
--
作者：
Assenat, E;Gerbal-Chaloin, S;Pascussi, JM
在过去的几年中，一些研究提供了核因子κ-B（NF-κ B）的组成性激活与癌症的发生和发展之间的因果关系。最近，似乎癌症诱导的炎症反应可能是癌症化疗反应和毒性作用的个体间变异性以及患者药物代谢酶表达改变的重要因素。慢性炎症与（或感染），癌症和药物代谢有很多：慢性感染导致炎症，炎症可能导致癌症，癌症通常导致炎症综合征，和炎症改变药物代谢酶的表达，从而改变癌症化疗的效率。肿瘤发生过程中的κ B活化和参与抗癌治疗的主要细胞色素P450（CYP）的表达。最后，讨论了NF-κ B B作为炎症、癌症和癌症患者肝脏药物代谢改变之间缺失环节的潜在作用。(c)2006爱思唯尔有限公司保留所有权利。
In the last few years, several studies have provided a causal link between constitutive activation of nuclear factor kappa-B (NF-kappa B) and the initiation and development of cancer. More recently, it appears that a cancer-induced inflammatory response may be an important factor in the inter-individual variability of the response to and toxic effects of cancer chemotherapy, as well as in the alteration of drug metabolism enzyme expression in patients. The relationships between chronic inflammation (or infection), cancer and drug metabolism are many: chronic infections lead to inflammation, inflammation may lead to cancer, cancer usually leads to an inflammatory syndrome, and inflammation alters the expression of drug metabolising enzymes and thus of the efficiency of cancer chemotherapy This review focuses on the functional consequences of NF-kappa B activation during oncogenesis and on the expression of the major cytochrome P450s (CYP) involved in anticancer therapies. Finally, the potential role of NF-kappa B as the missing link between inflammation, cancer and alteration in hepatic drug metabolism in patients with cancer is discussed. (c) 2006 Elsevier Ltd. All rights reserved.