Delayed consequences of endothelial removal from rabbit aortae.
Delayed consequences of endothelial removal from rabbit aortae.
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从兔主动脉去除内皮的延迟后果。
DOI：
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发表时间：
1978
影响因子：
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通讯作者：
C. Geiger
中科院分区：
文献类型：
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作者：
T. Spaet;C. Rhee;C. Geiger
用球囊导管去除兔主动脉内皮化一年后，损伤区显示动脉硬化增厚。在这里描述的研究中，6只兔的主动脉在单次损伤后2年进行了检查。3例为动脉粥样硬化晚期病变。所有的动物都喂了标准的兔粮，被测试的五只动物在被宰杀时没有高胆固醇血症。显然，血管损伤本身就是兔动脉粥样硬化性疾病发展的充分基础。
One year after de-endothelialization of rabbit aorta by a balloon catheter, the damaged areas show arteriosclerotic thickening. In the study described here, aortae from six rabbits were examined 2 years after the single injury. Three had advanced atherosclerotic lesions. All the animals had been fed standard rabbit chow, and the five tested did not have hypercholesterolemia when they were sacrificed. Apparently vascular injury alone is sufficient basis for development of atherosclerotic disease in the rabbit.