SAMBADENA Hyperpolarization of 13C-Succinate in an MRI: Singlet-Triplet Mixing Causes Polarization Loss
SAMBADENA Hyperpolarization of 13C-Succinate in an MRI: Singlet-Triplet Mixing Causes Polarization Loss
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DOI：
10.1002/open.201900139
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发表时间：
2019-06-01
期刊：
影响因子：
2.3
通讯作者：
Hoevener, Jan-Bernd
中科院分区：
文献类型：
--
作者：
Berner, Stephan;Schmidt, Andreas B.;Hoevener, Jan-Bernd
生物分子核自旋的超极化提供的信号增强是一种非常有前途的诊断成像技术。到目前为止，大多数C-13造影剂不得不在额外的、复杂的或成本密集的偏振器中进行偏振。最近，一种C-13造影剂对~gt；20%的原位超极化被证明是在没有偏振器的情况下，但在核磁共振系统的孔内。这种方法解决了使用超极化示踪剂的磁共振成像的一些挑战，即成本高，生产时间长，以及在转移到检测位置期间的极化损失。在这里，我们展示了在7T场强下，生物分子在水溶液中的第一次超极化。1-C-13，2，3-H-2(2)-琥珀酸酯的C-13核被极化到11%，对应的信号增强约18.000。在加氢反应过程中观察到了一些有趣的效应，这些效应导致了显著的极化损失。
The signal enhancement provided by the hyperpolarization of nuclear spins of biological molecules is a highly promising technique for diagnostic imaging. To date, most C-13-contrast agents had to be polarized in an extra, complex or cost intensive polarizer. Recently, the in situ hyperpolarization of a C-13 contrast agent to >20 % was demonstrated without a polarizer but within the bore of an MRI system. This approach addresses some of the challenges of MRI with hyperpolarized tracers, i. e. elevated cost, long production times, and loss of polarization during transfer to the detection site. Here, we demonstrate the first hyperpolarization of a biomolecule in aqueous solution in the bore of an MRI at field strength of 7 T within seconds. The C-13 nucleus of 1-C-13, 2,3-H-2(2)-succinate was polarized to 11 % corresponding to a signal enhancement of approximately 18.000. Interesting effects during the process of the hydrogenation reaction which lead to a significant loss of polarization have been observed.