Smart bioelectronic pacifier for real-time continuous monitoring of salivary electrolytes
Smart bioelectronic pacifier for real-time continuous monitoring of salivary electrolytes
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DOI：
10.1016/j.bios.2022.114329
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发表时间：
2022-05-01
影响因子：
12.6
通讯作者：
Yeo, Woon-Hong
中科院分区：
文献类型：
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作者：
Lim, Hyo-Ryoung;Lee, Soon Min;Yeo, Woon-Hong
监测电解质对重症监护病房的新生儿和婴儿至关重要。然而，黄金标准方法使用抽血，这是痛苦的，只能提供离散的测量。尽管基于唾液的检测提供了一种替代方案，但现有的设备由于其刚性、笨重的外形因素和缺乏唾液积累而无法实时、连续地监测电解质。在这里，我们介绍了一种智能、无线、生物电子奶嘴，用于监测新生儿的唾液电解质，它可以实时检测连续的钠和钾水平，而无需抽血。该微型系统有助于将超轻和低姿态的设备与商业安抚奶嘴无缝集成，而无需额外的固定装置或结构修改。便携式设备包括离子选择传感器，柔性电路和微流体通道，允许简化非侵入性电解质监测的测量方案。灵活的微流体通道能够从口腔连续有效地收集唾液。通过改变通道的表面性质和毛细管储层的结构，我们实现了粘性介质的可靠泵送，从而实现了快速校准和测量。系统中嵌入的传感器表现出良好的稳定性和灵敏度：钠和钾传感器分别为52和57 mV/ 10年。在重症监护病房对新生儿进行的体内研究表明，该设备在无诱导刺激的情况下基于自然唾液检测关键电解质的可行性和性能。
Monitoring electrolytes is critical for newborns and babies in the intensive care unit. However, the gold standard methods use a blood draw, which is painful and only offers discrete measures. Although salivary-based detection offers promise as an alternative, existing devices are ineffective for real-time, continuous monitoring of electrolytes due to their rigidity, bulky form factors, and lack of salivary accumulation. Here, we introduce a smart, wireless, bioelectronic pacifier for salivary electrolyte monitoring of neonates, which can detect real-time continuous sodium and potassium levels without a blood draw. The miniature system facilitates the seamless integration of the ultralight and low-profile device with a commercial pacifier without additional fixtures or structural modifications. The portable device includes ion-selective sensors, flexible circuits, and microfluidic channels, allowing simplified measurement protocols in non-invasive electrolyte monitoring. The flexible microfluidic channel enables continuous and efficient saliva collection from a mouth. By modifying the surface properties of the channels and the structure of the capillary reservoir, we achieve reliable pumping of the viscous medium for quick calibration and measurement. Embedded sensors in the system show good stability and sensitivity: 52 and 57 mV/decade for the sodium and potassium sensor, respectively. In vivo study with neonates in the intensive care unit captures the device's feasibility and performance in the natural saliva-based detection of the critical electrolytes without induced stimulation.