Smoking, family history and urinary tract infection are associated with primary biliary cirrhosis: A meta-analysis
Smoking, family history and urinary tract infection are associated with primary biliary cirrhosis: A meta-analysis
复制标题
吸烟、家族史和尿路感染与原发性胆汁性肝硬化相关：一项荟萃分析
DOI：
10.1111/j.1872-034x.2011.00806.x
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发表时间：
2011-06-01
影响因子：
4.2
通讯作者：
Zhong, Renqian
中科院分区：
文献类型：
--
作者：
Liang, Yan;Yang, Zaixing;Zhong, Renqian
目的：通过Meta分析为原发性胆汁性肝硬化（PBC）与吸烟及其他因素的关系提供更精确的证据。方法：检索PubMed、EMBASE、科克伦图书馆和中国知网数据库，截止日期为2010年12月31日。数据由两人独立提取。使用卡方检验统计量评估研究间效应的同质性，并通过I2进行量化。基于固定效应或随机效应模型计算比值比（OR）和95%置信区间（CI）。结果：根据纳入标准，共纳入5篇文献。采用固定效应模型，PBC与吸烟和PBC家族史的合并OR分别为1.67（95%CI = 1.41-1.92）和7.56（95%CI = 1.90-13.22）。采用随机效应模型，甲状腺疾病和尿路感染（UTI）的合并OR分别为3.08（95%CI = 0.84-5.32）和2.02（95%CI = 1.40-2.65）。通过Begg和Egger检验的factors.Conclusion：这项荟萃分析表明，吸烟，PBC和UTI家族史与PBC在白色人口的系统评价现有的研究，并仍有待验证，在其他人群中的出版偏见的证据。
Aim:This meta-analysis was conducted to provide more precise evidence for association between primary biliary cirrhosis (PBC) and smoking and some other factors.Methods:We searched the databases PubMed, EMBASE, Cochrane Library and China National Knowledge Infrastructure up to 31 December 2010. Data were extracted by two persons independently. Homogeneity of effects across studies was assessed using the chi 2-test statistic and quantified by I2. Odds ratio (OR) and 95% confidence intervals (CI) were calculated based on fixed- or random-effects models. The publication bias was analyzed by Egger and Begg tests.Results:A total of five studies were selected according to inclusion criteria. With the fixed-effects model, the pooled OR for PBC and smoking and family history of PBC were 1.67 (95% CI = 1.41-1.92) and 7.56 (95% CI = 1.90-13.22). With the random-effects model, the pooled OR for thyroid disease and urinary tract infection (UTI) were 3.08 (95% CI = 0.84-5.32) and 2.02 (95% CI = 1.40-2.65), respectively. No evidence of publication bias was observed by means of Begg and Egger tests for the factors.Conclusion:This meta-analysis suggested that smoking, family history of PBC and UTI were strongly associated with PBC in a white population by systematic review of five existing studies, and the association remains to be validated in other populations.