Olfactory deficits, cognition and negative symptoms in early onset psychosis
Olfactory deficits, cognition and negative symptoms in early onset psychosis
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DOI：
10.1016/j.schres.2005.07.028
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发表时间：
2005-12-15
影响因子：
4.5
通讯作者：
Malaspina, D
中科院分区：
文献类型：
--
作者：
Corcoran, C;Whitaker, A;Malaspina, D
背景资料：成人精神分裂症中常见的认知识别缺陷（SID）与阴性症状和智力低下有关。然而，气味识别尚未检查在青少年早发性精神病，其中诊断往往是模糊的，有很少的预后predictors.Method：我们研究了气味识别，诊断，神经心理学表现和症状在26个良好的特点，青少年早发性精神病，年龄11-17岁。SID存在于样本中，并且在精神分裂症和精神病性抑郁症患者中比在精神病NOS和双相障碍患者中更常见。在成人中，SID与更大的阴性症状和更低的语言智商显著相关。然而，语言智商与（和其他口头任务）的气味识别在这个儿科样本中的解释的关系，这两种类型的变量，以阴性症状。SID存在于这个患有精神病性障碍的年轻人样本中，并且与精神分裂症的典型特征特别相关，例如阴性症状和智力低下，但与双相情感障碍的特征无关，比如宏伟。SID是早发性精神病的一个特征，可能有助于预后。(c)2005 Elsevier B. V.保留所有权利。
Background: Smell identification deficits (SID) are common in adult schizophrenia, where they are associated with negative symptoms and lower intelligence. However, smell identification has not been examined in adolescents with early onset psychosis, wherein diagnosis is often obscure, and there are few prognostic predictors.Method: We examined smell identification, diagnosis, neuropsychological performance and symptoms in 26 well characterized adolescents with early onset psychosis, age 11-17 years.Results: SID existed in the sample and were more common in patients with schizophrenia and psychotic depression than in patients with psychosis NOS and bipolar disorder. As in adults, SID were significantly associated with greater negative symptoms and lower verbal IQ. However, the associations of verbal IQ (and other verbal tasks) to smell identification in this pediatric sample were explained by the relation of both of these types of variables to negative symptoms.Conclusions: SID existed across this sample of youths with psychotic disorder, and were specifically related to typical characteristics of schizophrenia, such as negative symptoms and lower intelligence, but not to features of bipolar disorder, such as grandiosity. SID is a characteristic of early onset psychosis that may be useful for prognostic purposes. (c) 2005 Elsevier B.V. All rights reserved.