Associations of circulating inflammatory biomarkers with risk factors for colorectal cancer in colorectal adenoma patients.
Associations of circulating inflammatory biomarkers with risk factors for colorectal cancer in colorectal adenoma patients.
复制标题
循环炎性生物标志物与结直肠癌患者结直肠癌的危险因素的关联。
DOI：
10.4137/bmi.s10092
复制
发表时间：
2012
影响因子：
3.8
通讯作者：
Bostick RM
中科院分区：
文献类型：
--
作者：
Hopkins MH;Flanders WD;Bostick RM
肥胖和中心性肥胖与结直肠癌风险相关，并与炎症有关。炎症是一种复杂的相互作用的反应，可以通过多种同时测量的细胞因子来最准确地概括。在这项横断面分析中，我们研究了结直肠腺瘤患者中循环血浆 C 反应蛋白 (CRP)、肿瘤坏死因子-α (TNF-α)、白细胞介素 6 (IL-6)、白细胞介素 8 (IL-8)、白细胞介素 1β (IL-1β) 的循环血浆水平以及联合炎症 z 评分与结直肠癌危险因素之间的关系。 = 92）。多变量逻辑回归用于研究细胞因子水平与结直肠肿瘤已知危险因素之间的关联。平均细胞因子水平往往随着体重指数 (BMI) 的增加而增加，与 CRP、IL-6 和综合炎症 z 评分相关的统计显着趋势（趋势 P 分别 < 0.001、0.02 和 <0.001）。炎症 z 评分与超重 (BMI 25–29.9 kg/m2)、肥胖 (BMI ≥ 30 kg/m2) 或腰臀比较高的关联比值比分别为 4.33（95% CI [置信区间], 1.04–18.00）、5.54（95% CI, 1.37–22.42）和4.09（95% CI，1.67-9.98）。我们的研究结果支持（1）炎症与全身和中心性肥胖增加之间的关联，以及（2）将综合炎症评分作为结直肠肿瘤危险因素的研究。
Obesity and central adiposity are associated with colorectal cancer risk and have been linked to inflammation. Inflammation is a complex, interactive response that may most accurately be summarized through multiple, simultaneously measured cytokines. In this cross-sectional analysis, we investigated associations of circulating plasma levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-1β (IL-1β), and a combined inflammation z score with risk factors for colorectal cancer in colorectal adenoma patients (n = 92). Multivariable logistic regression was used to investigate associations between cytokine levels and known risk factors for colorectal neoplasms. Mean cytokine levels tended to increase with increasing body mass index (BMI), with statistically significant trends in relation to CRP, IL-6, and the combined inflammation z score (P for trend < 0.001, 0.02, and <0.001, respectively). The odds ratios for associations of the inflammation z score with being overweight (BMI 25–29.9 kg/m2), obese (BMI ≥ 30 kg/m2), or having a high waist-to-hip ratio were 4.33 (95% CI [confidence interval], 1.04–18.00), 5.54 (95% CI, 1.37–22.42), and 4.09 (95% CI, 1.67–9.98), respectively. Our findings support (1) associations of inflammation with increased general and central adiposity and (2) investigation of a combined inflammation score as a risk factor for colorectal neoplasms.