The relationship between Insulin-like Growth Factor 1, sex steroids and timing of the pubertal growth spurt.
The relationship between Insulin-like Growth Factor 1, sex steroids and timing of the pubertal growth spurt.
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DOI：
10.1111/cen.12682
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发表时间：
2015-06
影响因子：
3.2
通讯作者：
Dunger DB
中科院分区：
文献类型：
--
作者：
Cole TJ;Ahmed ML;Preece MA;Hindmarsh P;Dunger DB
青春期的进展涉及复杂的激素级联反应，但激素的个体贡献，特别是IGF-1，是未知的。我们使用一种新的生长曲线分析方法重新分析了甜菜生长研究数据，以根据身高和激素水平的变化来探索青春期的克里思。来自英格兰萨默塞特甜菜的男学生（n = 54）和女学生（n = 70）于1981年招募，年龄为8/9岁，随访至16岁。每6个月记录一次身高和坦纳分期（生殖器、乳房、阴毛），并在子样本（24名男孩，27名女孩）中采集血液样本。通过放射免疫法测定血清IGF-1、睾酮（男孩）和雌二醇（女孩）。使用平移和旋转叠加（SITAR）方法的变体分析每个结局的个体生长曲线，该方法估计平均曲线和对应于大小、年龄和峰值速度幅度的受试者特异性随机效应。SITAR模型与数据拟合良好，身高、IGF-1、睾酮和雌二醇的方差分别为99%、65%、86%和47%，坦纳分期的方差为69-88%。在青春期，这些变量在个体中的值都急剧增加，不同变量的峰值速度年龄高度相关，特别是IGF-1与身高（女孩r = 0.74，男孩r = 0.92）。 IGF-1，像身高，性类固醇和坦纳阶段，在青春期急剧上升的个人，与上升的时间在个人内部紧密同步。这表明IGF-1可能在决定青春期的时间方面发挥重要作用。
Progress through puberty involves a complex hormonal cascade, but the individual contributions of hormones, particularly IGF‐1, are unknown. We reanalysed Chard growth study data to explore the tempo of puberty based on changes in both height and hormone levels, using a novel method of growth curve analysis. Schoolboys (n = 54) and girls (n = 70) from Chard, Somerset, England, recruited in 1981 at age 8/9 and followed to age 16. Every 6 months, height and Tanner stages (genitalia, breast, pubic hair) were recorded, and in a subsample (24 boys, 27 girls), blood samples were taken. Serum IGF‐1, testosterone (boys) and oestradiol (girls) were measured by radioimmunoassay. Individual growth curves for each outcome were analysed using variants of the super‐imposition by translation and rotation (SITAR) method, which estimates a mean curve and subject‐specific random effects corresponding to size, and age and magnitude of peak velocity. The SITAR models fitted the data well, explaining 99%, 65%, 86% and 47% of variance for height, IGF‐1, testosterone and oestradiol, respectively, and 69–88% for the Tanner stages. During puberty, the variables all increased steeply in value in individuals, the ages at peak velocity for the different variables being highly correlated, particularly for IGF‐1 vs height (r = 0·74 for girls, 0·92 for boys). IGF‐1, like height, the sex steroids and Tanner stages, rises steeply in individuals during puberty, with the timings of the rises tightly synchronized within individuals. This suggests that IGF‐1 may play an important role in determining the timing of puberty.