CHARACTERIZING SPINAL MUSCULAR ATROPHY WITH ELECTRICAL IMPEDANCE MYOGRAPHY
CHARACTERIZING SPINAL MUSCULAR ATROPHY WITH ELECTRICAL IMPEDANCE MYOGRAPHY
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DOI：
10.1002/mus.21784
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发表时间：
2010-12-01
期刊：
影响因子：
3.4
通讯作者：
Darras, Basil T.
中科院分区：
文献类型：
--
作者：
Rutkove, Seward B.;Shefner, Jeremy M.;Darras, Basil T.
电阻抗肌电图（EIM）是一种无创、无痛的神经肌肉疾病的评估技术，在这里，我们评估其在脊髓性肌萎缩症（SMA）的潜在应用。21例SMA患者和18例健康儿童使用市售阻抗器械进行肱二头肌和胫骨前肌EIM。还进行了手持测力仪和皮下脂肪厚度的超声评估。所有EIM参数在SMA患者和正常受试者之间以及2型和3型SMA患者之间均存在显著差异。此外，EIM将患者正确分类为2型或3型的准确率高达93%。多元回归分析证实了EIM和测力之间的强关联。这些结果证实，EIM可以准确地对SMA患者进行分类。由于EIM不需要患者的努力，并且应用迅速，因此它可能在未来的SMA临床试验中发挥有用的作用。肌肉神经42：915-921，2010
Electrical impedance myography (EIM) is a non-invasive, painless technique for the evaluation of neuromuscular disease, and here we evaluate its potential application in spinal muscular atrophy (SMA). Twenty-one SMA patients and 18 healthy children underwent EIM of biceps brachii and tibialis anterior using a commercially available impedance device. Hand-held dynamometry and ultrasound assessment of subcutaneous fat thickness were also performed. All EIM parameters differed significantly between both SMA patients and normal subjects and between type 2 and type 3 SMA patients. In addition, EIM had an accuracy level as high as 93% for correctly categorizing patients as type 2 or type 3. Multiple regression analyses confirmed a strong association between EIM and dynamometry. These results confirm that EIM can accurately categorize patients with SMA. Because EIM requires no patient effort and is rapid to apply, it may serve a useful role in future SMA clinical trials. Muscle Nerve 42: 915-921, 2010