Bacterial translocation in the normal human appendix parallels the development of the local immune system
Bacterial translocation in the normal human appendix parallels the development of the local immune system
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DOI：
10.1196/annals.1309.015
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Laissue, JA
中科院分区：
文献类型：
--
作者：
Gebbers, JO;Laissue, JA
实验模式和病理条件可能导致细菌易位（BT），即定植于肠道的土著细菌通过肠粘膜到达肠系膜淋巴结。然而，没有关于BT在正常人类肠道中的数据。我们确定了BT的发生及其程度，在组织学正常，偶然删除人的蠕虫状阑尾（VA）从不同年龄的个人和相关的研究结果与发展与年龄相关的淋巴组织。BT似乎与VA中GALT的正常抗原采样过程有关。它也与GALT的发展及其在成年期的维持平行。在出生后的前两周，当肠道细菌定植发展时，VA缺乏分泌型伊加的保护时，未检测到BT。此后，BT沿着当地GALT的发展而发生，第一年后GALT完全建成。细菌的生理吸收或侵入可能有助于（1）诱导对固有植物群的耐受性和（2）刺激GALT并使其正常发育。
Experimental modes and pathological conditions may result in bacterial translocation (BT), that is, the passage of indigenous bacteria colonizing the intestine through the intestinal mucosa to mesenteric lymph nodes. Yet no data are available on BT in the normal human gut. We determined the occurrence of BT and its extent in histologically normal, incidentally removed human vermiform appendices (VA) from individuals of different ages and correlated the findings with the development with age of associated lymphatic tissue. BT appears to pertain to normal antigen-sampling processes of the GALT in the VA. It also parallels the development of the GALT and its maintenance during adulthood. In the first two weeks after birth, when bacterial colonization of the gut evolves and when the VA lacks the protection of secretory IgA, BT was not detected. Thereafter, BT occurs along with development of the local GALT, which is fully built up after the first year. A physiological uptake of, or invasion by, bacteria may be instrumental (1) for tolerance induction against the indigenous flora and (2) for the stimulation and normal development of the GALT.