Associations of salivary cortisol levels with inflammatory markers: The Multi-Ethnic Study of Atherosclerosis
Associations of salivary cortisol levels with inflammatory markers: The Multi-Ethnic Study of Atherosclerosis
复制标题
DOI：
10.1016/j.psyneuen.2011.11.009
复制
发表时间：
2012-07-01
影响因子：
3.7
通讯作者：
Shea, S.
中科院分区：
文献类型：
--
作者：
DeSantis, A. S.;DiezRoux, A. V.;Shea, S.
已发现社会经济和心理社会因素与全身性炎症相关。虽然压力通常被认为是这些关联的一个贡献者，但没有人口研究调查过炎症和压力生物标志物之间的联系。目前的研究检查每日皮质醇谱和炎症标志物白细胞介素-6（IL-6），白细胞介素-10（IL-10）和肿瘤坏死因子（TNF-α）之间的关联，在869名成年人的人群为基础的样本中，连续多日重复测量皮质醇。IL-6水平较高的人皮质醇觉醒反应不太明显，每日下降幅度较小，皮质醇曲线下面积较高，在控制风险因素和其他细胞因子后，这种关联持续存在。TNF-a水平较高的人在清醒时皮质醇水平较低，并且每日下降幅度较小，尽管在控制炎症风险因素时与下降的相关性减弱。IL-10水平越高，皮质醇日下降幅度越小（p <0.10）。这项研究是第一个确定协会的基础皮质醇活动和炎症标志物在人口为基础的样本。研究结果是一致的可能性，HPA轴活动可能介导的社会心理压力和炎症过程之间的关联。额外的前瞻性数据是必要的，以澄清皮质醇和炎症标志物之间的关联的方向性。(c)2011爱思唯尔有限公司保留所有权利。
Socioeconomic and psychosocial factors have been found to be associated with systemic inflammation. Although stress is often proposed as a contributor to these associations, no population studies have investigated the links between inflammation and biomarkers of stress. The current study examines associations between daily cortisol profiles and inflammatory markers interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor (TNF-a) in a population-based sample of 869 adults with repeat measures of cortisol over multiple days. Persons with higher levels of IL-6 had a less pronounced cortisol awakening response, a less steep daily decline, and higher cortisol area under the curve for the day with associations persisting after controls for risk factors and other cytokines. Persons with higher levels of TNF-a had lower cortisol levels upon waking, and flatter daily decline, although associations with decline were attenuated when controlling for inflammatory risk factors. Higher levels of IL-10 were associated with marginally flatter daily cortisol decline (p < .10). This study is the first to identify associations of basal cortisol activity and inflammatory markers in a population based sample. Findings are consistent with the possibility that HPA axis activity may mediate associations between psychosocial stressors and inflammatory processes. Additional prospective data are necessary to clarify the directionality of associations between cortisol and inflammatory markers. (c) 2011 Elsevier Ltd. All rights reserved.