Differing clinical features in Aboriginal vs. non-Aboriginal children presenting with type 2 diabetes
Differing clinical features in Aboriginal vs. non-Aboriginal children presenting with type 2 diabetes
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DOI：
10.1111/j.1399-5448.2012.00859.x
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发表时间：
2012-09-01
影响因子：
3.4
通讯作者：
Dean, Heather
中科院分区：
文献类型：
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作者：
Amed, Shazhan;Hamilton, Jill K.;Dean, Heather
目的儿童2型糖尿病（T2 D）正在增加，并可能在不同人群中表现不同。本研究比较了土著儿童与高加索儿童和其他高危种族儿童诊断T2 D的临床特征。患者和方法本回顾性观察性研究使用了加拿大监测研究的数据，其中报告了新诊断的儿童T2 D病例（n = 227）。使用描述性统计量，比较不同种族组（包括土著人（n = 100）、高加索人（n = 57）和其他高风险种族组（n = 64））诊断T2 D时的临床特征。对居住在加拿大中部（马尼托巴/安大略西北部）的土著儿童（n = 74）和来自加拿大其他地区的土著儿童（n = 26）进行了比较。结果与白人儿童和其他高危种族儿童相比，原住民儿童年龄更小，肥胖程度更低，患多囊卵巢综合征和血脂异常的可能性更低（p < 0.05）。来自加拿大中部的土著儿童与来自加拿大其他地区的土著儿童在年龄、体重指数Z评分、T2 D家族史或黑棘皮病的存在方面没有差异。来自加拿大中部的土著儿童血红蛋白A1 c水平较低（p < 0.05），患血脂异常的可能性也低于来自其他地区的土著儿童（p < 0.05）。结论：新诊断的T2 D儿童的临床特征和合并症发生率在不同人群（高加索人，原住民和属于其他高风险种族群体的儿童）和不同的原住民人群（居住在加拿大中部的人与居住在加拿大其他地区的人）之间存在差异。未来的研究应该确定导致这些差异的特定遗传和环境因素。
Objectives Childhood type 2 diabetes (T2D) is increasing and may present differently across various populations. This study compares clinical features of T2D at diagnosis in Aboriginal children with Caucasian children and children from other high-risk ethnic groups. Patients and methods This retrospective observational study used data from a Canadian surveillance study where newly diagnosed cases of childhood T2D were reported (n = 227). Using descriptive statistics, clinical features at diagnosis of T2D were compared across different ethnic groups including Aboriginal (n = 100), Caucasian (n = 57), and other high-risk ethnic groups (n = 64). Comparisons were made between Aboriginal children living in central Canada (Manitoba/northwestern Ontario) (n = 74) and Aboriginal children from other regions of Canada (n = 26). Results Aboriginal children were younger, less obese, and less likely to have polycystic ovarian syndrome and dyslipidemia when compared to Caucasian children and children from other high-risk ethnic groups (p < 0.05). Aboriginal children from central Canada vs. those from other regions of Canada did not differ in age, body mass index z-score, family history of T2D, or presence of acanthosis nigricans. Those from central Canada had lower hemoglobin A1c levels (p < 0.05) and were less likely to have dyslipidemia than Aboriginal children from other regions (p < 0.05). Conclusions Clinical features and rates of comorbidity in children with newly diagnosed T2D differ across various populations (Caucasian, Aboriginal, and children who belong to other high-risk ethnic groups) and across distinct Aboriginal populations (those living in central Canada vs. those living in other regions of Canada). Future research should determine specific genetic and environmental factors that contribute to these differences.