Ocular Anterior Segment Biometry and High-Order Wavefront Aberrations During Accommodation
Ocular Anterior Segment Biometry and High-Order Wavefront Aberrations During Accommodation
复制标题
调节过程中眼前段生物测量和高阶波前像差。
DOI：
10.1167/iovs.13-11893
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发表时间：
2013-10-01
影响因子：
4.4
通讯作者：
Lu, Fan
中科院分区：
文献类型：
--
作者：
Yuan, Yimin;Shao, Yilei;Lu, Fan
目的.采用超长扫描深度光学相干断层扫描（UL-OCT）技术结合波前传感器，研究调节过程中眼前节生物测量与眼高阶像差（HOA）的关系。我们招募了35例年轻健康受试者的右眼（21例女性和14例男性;年龄，25.6 ± 3.1岁;等效球镜屈光不正，-0.41 ± 0.59屈光度[D]）。结合了定制的UL-OCT和波前传感器。他们能够对眼前段成像并测量调节期间的HOA。比较了两种状态下的生物特征维数和高阶像差的差异，并研究了它们之间的关系。与非屈光状态相比，屈光状态下前房深度、瞳孔直径和晶状体透镜表面曲率半径均显著减小，而透镜厚度和固定3 mm瞳孔大小的高阶像差均方根（HORMS）均显著增加（P < 0.01）。透镜前表面曲率半径的变化与HORMS的变化呈负相关（r =-0.370，P = 0.014）。在非屈光状态和屈光状态下，固定瞳孔大小的HORMS与瞳孔直径呈负相关（r分别为-0.532和-0.801，P < 0.01）。在调节过程中，眼前段生物测量和HOA发生显著变化。HOA的增加主要是由于调节期间透镜前表面的凸度增加。瞳孔的收缩可以帮助减少HOA。
PURPOSE. We investigated the relationships between the ocular anterior segment biometry and the ocular high-order aberrations (HOAs) during accommodation by combined ultralong scan depth optical coherence tomography (UL-OCT) and wavefront sensor.METHODS. We enrolled 35 right eyes of young healthy subjects (21 women and 14 men; age, 25.6 +/- 3.1 years; spherical equivalent refractive error, -0.41 +/- 0.59 diopters [D]). A custom-built UL-OCT and a wavefront sensor were combined. They were able to image the ocular anterior segment and to measure the HOAs during accommodation. The differences in the biometric dimensions and in the HOAs between the nonaccommodative and accommodative states were compared, and the relationships between them were investigated.RESULTS. Compared to the nonaccommodative condition, anterior chamber depth, pupil diameter, and radii of the crystalline lens surface curvatures decreased significantly, while the lens thickness and root-mean-square of high-order aberration (HORMS) of fixed 3-mm pupil size increased under the accommodative stimulus (P < 0.01). A negative correlation was found between the change in the radius of the lens anterior surface curvature and the change in HORMS (r = -0.370, P = 0.014). For nonaccommodative and accommodative conditions, HORMS for a fixed pupil size was correlated negatively with pupil diameter (r = -0.532 and -0.801, respectively, P < 0.01).CONCLUSIONS. The anterior segment biometry and the HOAs changed significantly during accommodation. The increase in HOAs mainly was due to the increased convexity of the anterior surface of the lens during accommodation. Contraction of the pupil may help to decrease HOAs.