Seroprevalence and risk factors of human cysticercosis and taeniasis prevalence in a highly endemic area of epilepsy in Bangoua, west Cameroon
Seroprevalence and risk factors of human cysticercosis and taeniasis prevalence in a highly endemic area of epilepsy in Bangoua, west Cameroon
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DOI：
10.1016/j.actatropica.2015.12.019
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发表时间：
2017-01-01
期刊：
影响因子：
2.7
通讯作者：
Ito, Akira
中科院分区：
文献类型：
--
作者：
Nkouawa, Agathe;Dschanou, Armel Romeo;Ito, Akira
由猪带绦虫幼虫引起的囊虫病在流行区和非流行区都是对公共卫生的严重威胁。脑囊虫病是一种中枢神经系统疾病，是流行地区癫痫的主要原因。这项研究是为了调查人类囊虫病，绦虫病和危险因素，以及它们与癫痫高度流行的喀麦隆西部班古阿癫痫的关系。384人中有12人（3.1%）对T小分子抗原有抗体反应。用ELISA法测定血清中的硒。免疫印迹显示，6人（1.6%）血清阳性相同的抗原。在61例癫痫患者中，仅1例免疫印迹阳性，两组间血清T抗体阳性率差异无统计学意义（P> 0.05）。癫痫组1例（1/61，1.6%），非癫痫组5例（5/323，1.5%）。此外，囊虫病与家庭食用自家屠宰的猪肉有关，而与其他因素无关。相对良好的卫生和养猪习惯削弱了养猪、食用猪肉、蔬菜和非饮用水等风险因素。粪便镜检未发现带绦虫卵。在这项研究中获得的所有数据表明，囊虫病可能不是在这个地区的癫痫的主要病原体。(C)2015 Elsevier B.V.版权所有。
Cysticercosis caused by the larvae of Taenia solium is a serious and emerging threat to public health in the endemic areas as well as in the non-endemic areas. Neurocysticercosis, an affection of the central nervous system is a leading cause of epilepsy in endemic areas. This study was carried out to investigate human cysticercosis, taeniasis and risk factors, and also their association with epilepsy in Bangoua, west Cameroon where epilepsy is highly prevalent. Out of 384 people investigated, 12 (3.1%) exhibited antibody response against low molecular weight antigens of T. solium by ELISA. Immunoblot revealed that six persons (1.6%) were seropositive with the same antigens. Among 61 epileptic patients, only one was seropositive by immunoblot and the study did not find any statistically significant difference (P > 0.05) in seropositivity to T. solium between epileptic persons (1/61, 1.6%) and non-epileptic group (5/323, 1.5%). In addition, cysticercosis was associated with households eating pork meat from pigs slaughtered at home, but not with other factors. The risk factors including pig farming, the consumption of pork meat, vegetables, and non-drinkable water were attenuated by the relatively good hygiene and pig husbandry practices of the population. No egg of Taenia was found in stool by microscopic examination. All data obtained in this study suggested that cysticercosis might not be the principal causative agent of epilepsy in this area. (C) 2015 Elsevier B.V. All rights reserved.