Analysis of Pharmacokinetics in the Cochlea of the Inner Ear.
Analysis of Pharmacokinetics in the Cochlea of the Inner Ear.
复制标题
内耳耳蜗中的药代动力学分析。
DOI：
10.3389/fphar.2021.633505
复制
发表时间：
2021
影响因子：
5.6
通讯作者：
Hibino H
中科院分区：
文献类型：
--
作者：
Sawamura S;Ogata G;Asai K;Razvina O;Ota T;Zhang Q;Madhurantakam S;Akiyama K;Ino D;Kanzaki S;Saiki T;Matsumoto Y;Moriyama M;Saijo Y;Horii A;Einaga Y;Hibino H
听力损失影响着全球超过5%的人口，因此具有巨大的社会和临床影响。感音神经性听力损失可能由不同的因素引起，例如声创伤，衰老和某些类别的药物的管理，主要源于内耳中的耳蜗功能障碍。很少有针对感音神经性听力损失的治疗策略。为了开发针对这种疾病的有效治疗方法，精确确定耳毒性和治疗剂在活体动物耳蜗微环境中的行为至关重要。自1980年代以来，一些研究通过不同的方法探讨了这一问题。然而，与其他器官相比，耳蜗中的药代动力学信息少得多;本体药理学的延迟可能是由于进入耳蜗的技术困难，耳蜗是一个被骨壁包裹的微小器官，具有精细而复杂的内部结构。在这篇综述中，我们不仅总结了在经典和最近的研究中获得的观察结果和见解在耳蜗药代动力学，但也描述了相关的分析技术，其优势，局限性和前景。
Hearing loss affects >5% of the global population and therefore, has a great social and clinical impact. Sensorineural hearing loss, which can be caused by different factors, such as acoustic trauma, aging, and administration of certain classes of drugs, stems primarily from a dysfunction of the cochlea in the inner ear. Few therapeutic strategies against sensorineural hearing loss are available. To develop effective treatments for this disease, it is crucial to precisely determine the behavior of ototoxic and therapeutic agents in the microenvironment of the cochlea in live animals. Since the 1980s, a number of studies have addressed this issue by different methodologies. However, there is much less information on pharmacokinetics in the cochlea than that in other organs; the delay in ontological pharmacology is likely due to technical difficulties with accessing the cochlea, a tiny organ that is encased with a bony wall and has a fine and complicated internal structure. In this review, we not only summarize the observations and insights obtained in classic and recent studies on pharmacokinetics in the cochlea but also describe relevant analytical techniques, with their strengths, limitations, and prospects.
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DOI：
10.1056/nejmra1616601
发表时间：
2017-12-21
期刊：
The New England journal of medicine
影响因子：
--
作者：
Cunningham LL;Tucci DL
通讯作者：
Tucci DL
影响因子：
2.8
作者：
Grondin, Yohann;Cotanche, Douglas A.;Rogers, Rick A.
通讯作者：
Rogers, Rick A.
影响因子：
3.8
作者：
Haghpanahi, Masoumeh;Gladstone, Miriam B.;Borkholder, David A.
通讯作者：
Borkholder, David A.
影响因子：
3.7
作者：
Chaurasia, Chandra S.;Mueller, Markus;Yeo, Helen
通讯作者：
Yeo, Helen
影响因子：
2.1
作者：
Crowson, Matthew Gordon;Hertzano, Ronna;Tucci, Debara L.
通讯作者：
Tucci, Debara L.