AMP-activated protein kinase regulation and biological actions in the heart.
AMP-activated protein kinase regulation and biological actions in the heart.
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DOI：
10.1161/circresaha.111.255505
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发表时间：
2012-08-31
影响因子：
20.1
通讯作者：
Young LH
中科院分区：
文献类型：
--
作者：
Zaha VG;Young LH
AMP 激活蛋白激酶 (AMPK) 是一种应激激活激酶，可充当细胞电量计和主要代谢调节剂。最近的研究阐明了 AMPK 调节的新分子机制以及与心血管疾病高度相关的 AMPK 通路的重要生物学作用。内在 AMPK 通路的激活在心肌对缺血、压力超负荷和心力衰竭的反应中起着重要作用。 AMPK 的药理学激活显示出作为治疗心脏病的治疗策略的前景。本综述的目的是评估最近的发现如何扩展并在某些情况下挑战现有的范式，为 AMPK 的调节、其多样化的生物作用和心脏治疗潜力提供新的见解。
AMP-activated protein kinase (AMPK) is a stress-activated kinase that functions as a cellular fuel gauge and master metabolic regulator. Recent investigation has elucidated novel molecular mechanisms of AMPK regulation and important biological actions of the AMPK pathway that are highly relevant to cardiovascular disease. Activation of the intrinsic AMPK pathway plays an important role in the myocardial response to ischemia, pressure overload and heart failure. Pharmacologic activation of AMPK shows promise as a therapeutic strategy in the treatment of heart disease. The purpose of this review is to assess how recent discoveries have extended and in some cases challenged existing paradigms, providing new insights into the regulation of AMPK, its diverse biological actions and therapeutic potential in the heart.