High-Intensity Exercise Enhances Conduit Artery Vascular Function in Older Adults.
High-Intensity Exercise Enhances Conduit Artery Vascular Function in Older Adults.
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DOI：
10.1249/mss.0000000000001405
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发表时间：
2018-01
影响因子：
4.1
通讯作者：
Casey DP
中科院分区：
文献类型：
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作者：
Iwamoto E;Bock JM;Casey DP
在年轻人中，血管功能的调节遵循运动强度依赖模式。本研究旨在探讨急性运动对健康老年人导管和阻力动脉功能的潜在强度依赖性影响。11名健康老年人（5男6女，66±1岁）在两次单独的研究访问中以年龄预测最大心率的50-55%（低强度）和75-80%（高强度）完成了30分钟的平躺自行车运动。在基线、运动后10分钟和运动后1小时分别测量肱动脉血流介导扩张（FMD）和反应性充血（RH）。此外，在运动过程中每5分钟测量一次心血管血流动力学和肱剪切速率。高强度运动后10 min肱动脉FMD增强（4.8±0.2 ~ 9.1±0.3%，P<0.01），低强度运动后10 min肱动脉FMD增强（4.7±0.2 ~ 6.2±0.3%，P=0.54）。运动后10分钟，两种强度（低强度峰值372±31 ~ 444±37，高强度峰值391±30 ~ 455±28 ml/min，低强度总142±16 ~ 205±20，高强度总158±14 ~ 240±25 ml，时间对两种强度的主要影响P<0.05） RH（阻力动脉功能指标）的峰值和总血流量（曲线下面积）均增强。然而，运动强度之间的峰值血流量和总血流量变化幅度没有差异（交互作用效应，P=0.56和P=0.97）。与运动强度无关，运动后1小时FMD恢复到基线水平（高5.9±0.3；低5.1±0.1%，P值均为0.05）。我们的数据表明，高强度运动能显著增强健康老年人的导管动脉功能。此外，急性运动可以增强动脉的抗阻功能，而不受运动强度的影响。
Modulation of vascular function follows an exercise intensity-dependent pattern in young adults. This study aimed to investigate the potential intensity-dependent effects of an acute bout of exercise on conduit and resistance artery function in healthy older adults. Eleven healthy older adults (5 males/6 females, 66±1 years) completed 30 minutes of recumbent cycling at 50–55% (low-intensity) and 75–80% (high-intensity) of their age-predicted maximal heart rate on two separate study visits. Doppler ultrasound measures of brachial artery flow-mediated dilation (FMD) and reactive hyperemia (RH) were taken at baseline, ten minutes post-exercise, and one hour post-exercise. Additionally, cardiovascular hemodynamics and brachial shear rate were measured every five minutes during exercise. Brachial artery FMD was enhanced ten minutes after high-intensity (4.8±0.2 to 9.1±0.3%, P<0.01), but not low-intensity (4.7±0.2 to 6.2±0.3%, P=0.54) exercise. Peak and total (area under the curve) blood flow during RH (measures of resistance artery function) were enhanced ten minutes post-exercise for both intensities (peak low-intensity 372±31 to 444±37, peak high-intensity 391±30 to 455±28 ml/min; total low-intensity 142±16 to 205±20, total high-intensity 158±14 to 240±25 ml, main effect of time for both P<0.05). However, the magnitude of change in peak and total blood flow were not different between exercise intensities (interaction effect; P=0.56 and P=0.97, respectively). Independent of exercise intensity, FMD returned to baseline one-hour after exercise (high 5.9±0.3; low 5.1±0.1%, both P>0.05). Our data indicate that high-intensity exercise acutely enhances conduit artery function in healthy older adults. Additionally, an acute bout of exercise enhances resistance artery function independent of intensity.