Ventral tegmental nucleus of Gudden: A pontine hippocampal theta generator?
Ventral tegmental nucleus of Gudden: A pontine hippocampal theta generator?
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DOI：
10.1002/hipo.1096
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发表时间：
2001-01-01
期刊：
影响因子：
3.5
通讯作者：
Poindessous-Jazat, F
中科院分区：
文献类型：
--
作者：
Bassant, MH;Poindessous-Jazat, F
众所周知，内侧间隔的节律性爆发（RB）活动对海马波节律的产生至关重要，但其他间脑-脑桥结构的作用却鲜有文献记载。Gudden的腹侧被盖核（VTn）通过与内侧乳状核的相互连接与Papez回路相关，因此它可能在海马theta的产生中发挥作用。在本研究中，我们记录了未麻醉的受限大鼠（n = 9） VTn神经元的细胞外活动。同时记录海马活动（EEG）和肌电图以识别睡眠-清醒状态。在清醒、海马波和快速眼动（REM）睡眠期间，观察到VTn的RB活动。VTn的节律性先于海马的θ波活动。VTn中RB神经元的频率在清醒时为5.6 Hz，在REM睡眠时为6.8 Hz。这和海马体的相似。在快速眼动睡眠期间，节律性特别稳定，放电率惊人地高。在脲麻醉率下也记录了VTn中的RB活性（n = 3）。节律性放电（4.0 Hz）比未麻醉的大鼠慢，与氨基甲酸酯相关的θ波频率相匹配。我们的研究结果表明，VTn的神经元在伴随海马theta节律的警觉状态下表现出明显的RB活动。他们认为VTn可能是脑桥海马波的产生器。海马体11:809 2001;813年。(C) 2001 Wiley-Liss, Inc。
It is well-established that rhythmically bursting (RB) activity in the medial septum is crucial for the generation of the hippocampal theta rhythm, but the contribution of other diencephalic-pontine structures is less documented. The ventral tegmental nucleus (VTn) of Gudden is related to the Papez's circuit via its interconnections with the medial mammillary nucleus, and therefore it may play a role in the generation of hippocampal theta. In the present study, extracellular activity from VTn neurons were recorded in unanesthetized restrained rats (n = 9). Hippocampal activity (EEG) and electromyograms were recorded simultaneously to identify sleep-waking states. RB activity was observed in VTn during wakefulness, with periods of hippocampal theta and during rapid eye movement (REM) sleep. Rhythmicity in VTn preceded theta activity in hippocampus. The frequency of RB neurons in VTn was 5.6 Hz during wakefulness and 6.8 Hz during REM sleep. It was similar to that of hippocampal theta. The rhythmicity was particularly stable and the firing rates were strikingly high during REM sleep. RB activity in VTn was also recorded from urethane-anesthetized rates (n = 3). Rhythmic firing (4.0 Hz) was slower than in unanesthetized rats and matched the urethane-related theta frequency. Our results show that neurons in VTn exhibit a marked RB activity during states of vigilance accompanied by hippocampal theta rhythm. They suggest that VTn may be a pontine hippocampal theta generator. Hippocampus 2001;11:809-813. (C) 2001 Wiley-Liss, Inc.