CLINICAL SIGNIFICANCE OF ANTIBODY TO THE HEPATITIS DELTA VIRUS IN SYMPTOMLESS HBsAg CARRIERS
CLINICAL SIGNIFICANCE OF ANTIBODY TO THE HEPATITIS DELTA VIRUS IN SYMPTOMLESS HBsAg CARRIERS
复制标题
无症状 HBsAg 携带者中丁型肝炎病毒抗体的临床意义
DOI：
10.1016/s0140-6736(85)92497-3
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
A. Craxì
中科院分区：
文献类型：
--
作者：
S. Aricó;M. Rizzetto;A. Zanetti;S. Diana;M. Arnone;A. Ascione;G. Pastore;M. Aragona;F. Caredda;G. Marinucci;P. Farci;N. Caporaso;P. Dentico;G. Raimondo;A. Craxì
Antibody to the hepatitis delta virus (anti-δ) was detected in 112 out of 2487 (5%) individuals fortuitously found to have the hepatitis B surface antigen (HBsAg) in the blood. Liver function was impaired in 38% (43 of 112) of the anti-δ-positive carriers but in only 9% (215 of 2375) of the anti-δ-negative subjects (p<0·001). Liver biopsy specimens were obtained from 31 antibody-positive and 97 antibody-negative subjects with impaired liver function. Important histological changes were observed in 61% of the 31 antibody-positive carriers (7 chronic active hepatitis, 4 active cirrhosis, 8 inactive cirrhosis) but in only 19% of the 97 antibody-negative carriers (p<0·001). The presence of anti-δ in serum identifies a subpopulation of apparently healthy HBsAg carriers whose risk of underlying liver disease is four times higher than that in the ordinary carrier. The identification of anti-δ in a symptom-free HBsAg carrier with abnormal liver function is thus an indication for a diagnostic liver biopsy.
