EARLY ESTROGEN ACTION - CONCOMITANT STIMULATIONS WITHIN 2 MINUTES OF NUCLEAR RNA SYNTHESIS AND UPTAKE OF RNA PRECURSOR BY UTERUS
EARLY ESTROGEN ACTION - CONCOMITANT STIMULATIONS WITHIN 2 MINUTES OF NUCLEAR RNA SYNTHESIS AND UPTAKE OF RNA PRECURSOR BY UTERUS
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DOI：
10.1073/pnas.56.5.1594
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发表时间：
1966-01-01
影响因子：
11.1
通讯作者：
HAMILTON, TH
中科院分区：
文献类型：
--
作者：
MEANS, AR;HAMILTON, TH
雌激素在2分钟内刺激子宫合成核糖核酸和摄取核糖核酸前体。给去卵巢的成年大鼠注射激素后。这些效应的直接性清楚地表明，雌激素以某种未知的方式刺激细胞膜活性和DNA转录。这导致了几个特定的RNA分子的非常快速的合成，这些分子可能启动并支持随后刺激子宫蛋白质合成。
Estrogen stimulates both the synthesis of nuclear RNA and the uptake of RNA precursor by the uterus within 2 min. following administration of the hormone to the ovariectomized adult rat. The immediacy of these effects clearly illustrates that estrogen in some unknown way stimulates membrane activity and transcription of DNA. This results in a very rapid synthesis of a few specific molecules of RNA which presumably initiate and support the subsequent stimulation of uterine protein synthesis.