The genetic hypothesis for the transmission of Australia antigen (HBsAg).
The genetic hypothesis for the transmission of Australia antigen (HBsAg).
复制标题
澳大利亚抗原（HBsAg）传播的遗传假说。
DOI：
10.1002/ajpa.1330490214
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发表时间：
1978
影响因子：
2.8
通讯作者：
D. G. Smith
中科院分区：
文献类型：
--
作者：
D. G. Smith
例外已被引用，这对澳大利亚抗原（HBsAg）易感性传播的简单常染色体隐性假设规则。本文试图提出一种遗传模型，对一组新的、独特的数据进行复杂的分离分析，以检验这一假设。回归技术用于估计四个人群的年龄和性别特异性外显率水平以及假设产物为HBsAg的基因的频率。虽然遗传假说没有得到普遍支持，但对观察到的偏差及其可能的原因进行了讨论。
Exceptions have been cited which rule against the simple autosomal recessive hypothesis for the transmission of susceptibility to infection with Australia antigen (HBsAg). An attempt is made here to present a genetic model for a complex segregation analysis of a new and unique set of data to test this hypothesis. Regression techniques were used to estimate in four populations, age and sex-specific penetrance levels and the frequency of the gene whose product is hypothesized to be HBsAg. While the genetic hypothesis was not in general supported, observed deviations and their possible causes are discussed.