Situational determinants of cardiovascular and emotional reactivity in high and low hostile men.
Situational determinants of cardiovascular and emotional reactivity in high and low hostile men.
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DOI：
10.1097/00006842-198907000-00004
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发表时间：
1989-07
影响因子：
3.3
通讯作者：
Edward C. Suarez;Redford B. Williams
中科院分区：
文献类型：
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作者：
Edward C. Suarez;Redford B. Williams
&NA;各种流行病学研究发现，Cook和Medley敌意（Ho）量表的高分与冠心病（CHD）风险增加、动脉粥样硬化严重程度和全因死亡率相关。一种可能导致CHD风险增加的合理生物学机制是交感神经系统介导的对环境应激的高反应性。本研究评估了心血管反应的年轻男子高与低Ho分数在执行一个字谜任务有或没有骚扰。与单独执行任务相比，骚扰导致心血管唤醒增加，高Ho受试者比低Ho受试者更明显。此外，骚扰会增加自评的愤怒、刺激和紧张，但只有在Ho分数高的受试者中，愤怒和刺激的增加与心血管唤醒的增强有关。虽然表明愤怒和刺激诱导的心血管觉醒在CHD发病机制中的作用，但这些研究结果表明，情境特征介导了Ho评分和心血管反应之间的关系，并且在具有高和低Ho评分的男性中，愤怒/刺激和心血管反应之间可能存在不同的生物学联系。
&NA; Various epidemiologic studies have found that high scores on the Cook and Medley Hostility (Ho) scale are associated with increased risk of coronary heart disease (CHD), severity of atherosclerosis, and all‐cause mortality. One plausible biological mechanism suspected of contributing to increased risk of CHD is sympathetic nervous system‐mediated hyperresponsivity to environmental stressors. The present study evaluated cardiovascular reactivity among young men with high versus low Ho scores during performance of an anagram task with or without harassment. Compared to performing the task alone, harassment led to increased cardiovascular arousal that was more pronounced for the high Ho subjects than the low Ho subjects. Moreover, harassment produced increases in self‐rated anger, irritation, and tension, but it was only among those subjects with high Ho scores that increased anger and irritation were associated with enhanced cardiovascular arousal. While suggesting a role for anger‐ and irritation‐induced cardiovascular arousal in pathogenesis of CHD, these findings indicate that situation characteristics mediate the relationship between Ho scores and cardiovascular reactivity, and that there may be a differential biological link between anger/irritation and cardiovascular responses in men with high and low Ho scores.