Imaging in Radiation Oncology: A Perspective
Imaging in Radiation Oncology: A Perspective
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DOI：
10.1634/theoncologist.2009-s106
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发表时间：
2010-01-01
期刊：
影响因子：
5.8
通讯作者：
Menard, Cynthia
中科院分区：
文献类型：
--
作者：
Dawson, Laura A.;Menard, Cynthia
放射治疗的固有目标是向肿瘤提供足够的剂量以根除所有癌细胞或减轻症状，同时避免正常组织损伤。用于癌症诊断、分期、治疗计划和放射靶向的成像已经以各种方式整合，以提高发生这种情况的机会。随着放射治疗的发展，大量的成像策略和技术也在不断发展。成像的类型可以分为离线成像（治疗室外）和在线成像（治疗室内，通常称为图像引导放射治疗）。在放射治疗计划过程中直接整合图像（物理或计算）通常需要在成像性能方面进行权衡。尽管考虑到特定的临床目标，这种妥协可能是可以接受的，但随着辐射输送范式的发展以解决潜在的生物学问题并适应辐射反应，预计对成像性能的一般要求将会增加。本文回顾了影像学和放射肿瘤学的整合，并讨论了提高放射肿瘤学与影像学实践的挑战和机遇。肿瘤学家2010; 15：338-349
An inherent goal of radiation therapy is to deliver enough dose to the tumor to eradicate all cancer cells or to palliate symptoms, while avoiding normal tissue injury. Imaging for cancer diagnosis, staging, treatment planning, and radiation targeting has been integrated in various ways to improve the chance of this occurring. A large spectrum of imaging strategies and technologies has evolved in parallel to advances in radiation delivery. The types of imaging can be categorized into offline imaging (outside the treatment room) and online imaging (inside the treatment room, conventionally termed image-guided radiation therapy). The direct integration of images in the radiotherapy planning process (physically or computationally) often entails trade-offs in imaging performance. Although such compromises may be acceptable given specific clinical objectives, general requirements for imaging performance are expected to increase as paradigms for radiation delivery evolve to address underlying biology and adapt to radiation responses. This paper reviews the integration of imaging and radiation oncology, and discusses challenges and opportunities for improving the practice of radiation oncology with imaging. The Oncologist 2010; 15: 338-349