Sexual selection and the adaptive evolution of PKDREJ protein in primates and rodents.
Sexual selection and the adaptive evolution of PKDREJ protein in primates and rodents.
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灵长类和啮齿类动物的性选择和 PKDREJ 蛋白的适应性进化。
DOI：
10.1093/molehr/gau095
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发表时间：
2015
影响因子：
4
通讯作者：
Roldan,EduardoRS
中科院分区：
文献类型：
--
作者：
Vicens,Alberto;GómezMontoto,Laura;Couso-Ferrer,Francisco;Sutton,KeithA;Roldan,EduardoRS
PKDREJ 是一种睾丸特异性蛋白质，被认为位于精子表面。对小鼠的功能研究表明，PKDREJ 的缺失会影响精子运输和进行诱导顶体反应的能力。因此，PKDREJ 被认为是精子竞争形式的交配后性选择的潜在目标。参与生殖过程的蛋白质通常表现出加速进化。在许多情况下，这种快速分化是由正选择促进的，而正选择可能至少部分是由交配后性选择驱动的。我们分析了灵长类动物和啮齿类动物中 PKDREJ 蛋白的进化，并评估了 PKDREJ 分歧是否与相对于体重的睾丸质量有关，睾丸质量是精子竞争水平的可靠指标。在灵长类动物中没有发现 PKDREJ 基因的进化速率和相对于体重的睾丸质量之间存在关联的证据。在啮齿类动物中，在仓鼠科的 Pkdrej 基因中检测到了正选择的证据，但在鼠科中却没有检测到。然后我们评估了 Pkdrej 分歧是否与这些家庭中的精子竞争事件有关。我们发现，仓鼠的 Pkdrejand 睾丸质量相对于体重的进化速率之间存在显着正相关。这些发现构成了交配后性选择影响参与调节精子运输和顶体反应机制的蛋白质进化的第一个证据，强烈表明正选择可能作用于这些受精步骤，从而在精子竞争的情况下产生优势。
PKDREJ is a testis-specific protein thought to be located on the sperm surface. Functional studies in the mouse revealed that loss of PKDREJ has effects on sperm transport and the ability to undergo an induced acrosome reaction. Thus, PKDREJ has been considered a potential target of post-copulatory sexual selection in the form of sperm competition. Proteins involved in reproductive processes often show accelerated evolution. In many cases, this rapid divergence is promoted by positive selection which may be driven, at least in part, by post-copulatory sexual selection. We analysed the evolution of the PKDREJ protein in primates and rodents and assessed whether PKDREJ divergence is associated with testes mass relative to body mass, which is a reliable proxy of sperm competition levels. Evidence of an association between the evolutionary rate of thePKDREJgene and testes mass relative to body mass was not found in primates. Among rodents, evidence of positive selection was detected in thePkdrejgene in the family Cricetidae but not in Muridae. We then assessed whetherPkdrejdivergence is associated with episodes of sperm competition in these families. We detected a positive significant correlation between the evolutionary rates ofPkdrejand testes mass relative to body mass in cricetids. These findings constitute the first evidence of post-copulatory sexual selection influencing the evolution of a protein that participates in the mechanisms regulating sperm transport and the acrosome reaction, strongly suggesting that positive selection may act on these fertilization steps, leading to advantages in situations of sperm competition.