Further evidence for family-genetic risk factors in attention deficit hyperactivity disorder. Patterns of comorbidity in probands and relatives psychiatrically and pediatrically referred samples.
Further evidence for family-genetic risk factors in attention deficit hyperactivity disorder. Patterns of comorbidity in probands and relatives psychiatrically and pediatrically referred samples.
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DOI：
10.1001/archpsyc.1992.01820090056010
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发表时间：
1992-09
影响因子：
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通讯作者：
J. Biederman;S. Faraone;K. Keenan;J. Benjamin;B. Krifcher;Cynthia Moore;S. Sprich-Buckminster;
中科院分区：
文献类型：
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作者：
J. Biederman;S. Faraone;K. Keenan;J. Benjamin;B. Krifcher;Cynthia Moore;S. Sprich-Buckminster;
我们采用“盲”评定法和结构化诊断访谈法对140名注意缺陷多动障碍先证者、120名正常对照者及其822名一级亲属进行了检查。与对照组相比，注意力缺陷多动障碍的先证者更可能有行为、情绪和焦虑障碍。与对照组的亲属相比，注意缺陷多动障碍先证者的亲属患注意缺陷多动障碍、反社会障碍、重性抑郁障碍、物质依赖和焦虑障碍的风险更高。共病模式表明，注意缺陷多动障碍和重性抑郁障碍可能有共同的家庭脆弱性，注意缺陷多动障碍加品行障碍可能是一个独特的亚型，注意缺陷多动障碍和焦虑症是独立的家庭传播。这些结果扩展了以前的研究结果表明，家庭遗传的影响，在注意缺陷多动障碍，使用儿科和精神病学参考先证者样本。共病在家族中的分布为通过共病将注意缺陷多动障碍先证者分组提供了进一步验证。
We examined 140 probands with attention deficit hyperactivity disorder, 120 normal controls, and their 822 first-degree relatives using "blind" raters and structured diagnostic interviews. Compared with controls, probands with attention deficit hyperactivity disorder were more likely to have conduct, mood, and anxiety disorders. Compared with relatives of controls, relatives of probands with attention deficit hyperactivity disorder had a higher risk for attention deficit hyperactivity disorder, antisocial disorders, major depressive disorder, substance dependence, and anxiety disorders. Patterns of comorbidity indicate that attention deficit hyperactivity disorder and major depressive disorders may share common familial vulnerabilities, that attention deficit hyperactivity disorder plus conduct disorder may be a distinct subtype, and that attention deficit hyperactivity disorder and anxiety disorders are transmitted independently in families. These results extend previous findings indicating family-genetic influences in attention deficit hyperactivity disorder by using both pediatrically and psychiatrically referred proband samples. The distributions of comorbid illnesses in families provide further validation for subgrouping probands with attention deficit hyperactivity disorder by comorbidity.