Association of antenatal depression with oxidative stress and impact on spontaneous preterm birth.
Association of antenatal depression with oxidative stress and impact on spontaneous preterm birth.
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产前抑郁症与氧化应激的关联及其对自发性早产的影响。
DOI：
10.1038/s41372-019-0317-x
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Ferguson,KellyK
中科院分区：
文献类型：
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作者：
Venkatesh,KartikK;Meeker,JohnD;Cantonwine,DavidE;McElrath,ThomasF;Ferguson,KellyK
目的探讨产前抑郁是否与氧化应激和炎症相关，以及产后抑郁与自发性早产（SPTB）之间的关联是否由这些生物标志物介导。研究设计主要结果包括尿液氧化应激生物标志物8-羟基脱氧鸟苷（8-OHdG）和8-异前列腺素，以及血浆炎症生物标志物，分别在10、18和26周测量，并在个体内平均。采用线性和逻辑回归模型，调整年龄、种族、胎次和孕前体重指数。结果在462名女性中，8-异前列腺素在抑郁女性中较高（几何平均值：299.96 pg/mL vs 237.01 pg/mL;p= 0.001）。在多变量分析中，产前抑郁与平均8-异前列腺素升高显著相关（β: 0.25; 95% CI: 0.05-0.44;p= 0.01）。产前抑郁与SPTB的关联部分由8-异前列腺素介导。产前抑郁与8-OHdG或炎症生物标志物无关。结论孕期抑郁与妊娠期氧化应激（8-异前列腺素）升高有关，并可能通过氧化应激影响SPTB。
ObjectiveTo determine whether antenatal depression is associated with oxidative stress and inflammation, and secondarily, whether the association between antenatal depression and spontaneous preterm birth (SPTB) is mediated by these biomarkers.Study designThe primary outcome included urine oxidative stress biomarkers 8-hydroxydeoxyguanosine (8-OHdG) and 8-isoprostane and plasma inflammatory biomarkers measured at 10, 18, and 26 weeks and averaged within individual. Linear and logistic regression models were used, adjusting for age, race, parity, and pre-pregnancy body mass index.ResultsAmong 462 women, 8-isoprostane was higher among depressed women (geometric mean: 299.96 pg/mL vs. 237.01 pg/mL;p= 0.001). In multivariable analyses, antenatal depression was significantly associated with an increase in average 8-isoprostane (β: 0.25; 95% CI: 0.05–0.44;p= 0.01). The association of antenatal depression with SPTB was partially mediated by 8-isoprostane. Antenatal depression was not associated with 8-OHdG or inflammatory biomarkers.ConclusionsAntenatal depression was associated with higher oxidative stress across pregnancy, namely 8-isoprostane, and may impact SPTB via oxidative stress.