Patients' treatment expectancies in clinical trials of antidepressants versus psychotherapy for depression: a study using hypothetical vignettes.

Patients' treatment expectancies in clinical trials of antidepressants versus psychotherapy for depression: a study using hypothetical vignettes.
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抗抑郁药与抑郁症心理治疗临床试验中患者的治疗预期:一项使用假设小插曲的研究。

DOI:
10.1016/j.comppsych.2012.06.003
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发表时间:
2013
影响因子:
7.3
通讯作者:
Miller,IvanW
Miller,IvanW
中科院分区:
医学2区
文献类型:
--
作者:
Gaudiano,BrandonA;Hughes,JessicaA;Miller,IvanW

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Previous research on patients’ expectancies for improvement in clinical trials typically has been conducted after patients have already agreed to participate in a study. Depressed patients (n = 55) read 3 vignettes describing hypothetical clinical trials of antidepressant vs pill placebo, antidepressant vs antidepressant, and psychotherapy vs psychotherapy. Patients reported greater overall acceptability for psychotherapy over antidepressants. Patients had significantly greater expectancies for symptom reduction in either active comparator (medication or psychotherapy) compared with the placebo-controlled design. They also reported greater anticipated improvement and willingness to participate in the psychotherapy trial compared with either medication trial design. Patients’ differential expectancies based on study design could lead to different patient populations being selected for these studies and influence clinical improvement.
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