Acute Myeloid Leukemia Diagnosis in the 21st Century
Acute Myeloid Leukemia Diagnosis in the 21st Century
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DOI：
10.1043/2010-0245-ra.1
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发表时间：
2010-10-01
影响因子：
4.6
通讯作者：
Hess, Jay L.
中科院分区：
文献类型：
--
作者：
Betz, Bryan L.;Hess, Jay L.
上下文。对急性髓性白血病分子生物学的快速了解正在改变这些病例的诊断、预后和治疗方法。-简要回顾AML分类的现状，特别强调分子研究的作用及其对急性髓系白血病和其他恶性肿瘤治疗的影响。数据源。-当前文献和作者的经验。虽然形态学、免疫表型、细胞遗传学和临床病史继续发挥重要作用，但现在需要越来越多的分子检测来正确分类这些病例。（Arch Pathol Lab Med. 2010;134:1427-1433）
Context.-Rapid advances in understanding the molecular biology of acute myeloid leukemia are transforming the approach to diagnosis, prognostication, and treatment of these cases.Objective.-To briefly review the current state of AML classification with a particular emphasis on the role of molecular studies and their impact on the management of acute myeloid leukemia and other malignancies.Data Sources.-Current literature and experience of the authors.Conclusions.-While morphology, immunophenotyping, cytogenetics, and clinical history continue to play an important role, an increasing number of molecular tests are now required to properly classify these cases. (Arch Pathol Lab Med. 2010;134:1427-1433)