Molecular mechanisms mediating mitochondrial dynamics and mitophagy and their functional roles in the cardiovascular system.
Molecular mechanisms mediating mitochondrial dynamics and mitophagy and their functional roles in the cardiovascular system.
复制标题
DOI：
10.1016/j.yjmcc.2014.09.019
复制
发表时间：
2015-01
影响因子：
5
通讯作者：
Sadoshima, Junichi
中科院分区：
文献类型：
--
作者：
Ikeda, Yoshiyuki;Shirakabe, Akihiro;Brady, Christopher;Zablocki, Daniela;Ohishi, Mitsuru;Sadoshima, Junichi
线粒体是产生细胞能量来源--三磷酸腺苷的重要细胞器。功能障碍的线粒体参与了心脏病的病理生理过程，这与ATP水平降低和活性氧产生过多有关。线粒体是动态细胞器，通过分裂和融合改变其形态，以维持其功能。Fusion连接相邻的去极化线粒体，并混合它们的内容以维持膜电位。相反，裂变将受损的线粒体与完整的线粒体分开，受损的线粒体受到有丝分裂的影响，而完整的线粒体受到融合。人们普遍认为，线粒体融合对心脏有益，特别是在压力条件下，因为它巩固了线粒体的能量供应能力。然而，过度融合和不充分分裂都扰乱了线粒体质量控制机制，加剧了细胞死亡。在这篇综述中，我们讨论了线粒体动力学和有丝分裂在心脏和心肌细胞中的作用，重点讨论了它们在心血管疾病中的作用。
Mitochondria are essential organelles that produce the cellular energy source, ATP. Dysfunctional mitochondria are involved in the pathophysiology of heart disease, which is associated with reduced levels of ATP and excessive production of reactive oxygen species. Mitochondria are dynamic organelles that change their morphology through fission and fusion in order to maintain their function. Fusion connects neighboring depolarized mitochondria and mixes their contents to maintain membrane potential. In contrast, fission segregates damaged mitochondria from intact ones, where the damaged part of mitochondria is subjected to mitophagy whereas the intact part to fusion. It is generally believed that mitochondrial fusion is beneficial for the heart, especially under stress conditions, because it consolidates the mitochondria's ability to supply energy. However, both excessive fusion and insufficient fission disrupt the mitochondrial quality control mechanism and potentiate cell death. In this review, we discuss the role of mitochondrial dynamics and mitophagy in the heart and the cardiomyocytes therein, with a focus on their roles in cardiovascular disease.
登录
查看更多内容
影响因子：
10.8
作者：
Chen, Le;Gong, Qizhi;Knowlton, Anne A.
通讯作者：
Knowlton, Anne A.
影响因子：
21.3
作者：
通讯作者：
--
影响因子：
3.4
作者：
Dorn GW 2nd
通讯作者：
Dorn GW 2nd
影响因子：
4.5
作者：
Ashrafian H;Docherty L;Leo V;Towlson C;Neilan M;Steeples V;Lygate CA;Hough T;Townsend S;Williams D;Wells S;Norris D;Glyn-Jones S;Land J;Barbaric I;Lalanne Z;Denny P;Szumska D;Bhattacharya S;Griffin JL;Hargreaves I;Fernandez-Fuentes N;Cheeseman M;Watkins H;Dear TN
通讯作者：
Dear TN
影响因子：
20.1
作者：
Chen Y;Csordás G;Jowdy C;Schneider TG;Csordás N;Wang W;Liu Y;Kohlhaas M;Meiser M;Bergem S;Nerbonne JM;Dorn GW 2nd;Maack C
通讯作者：
Maack C