An optimized and highly repeatable MRI acquisition and processing pipeline for quantitative susceptibility mapping in the head-and-neck region
An optimized and highly repeatable MRI acquisition and processing pipeline for quantitative susceptibility mapping in the head-and-neck region
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DOI：
10.1002/mrm.28377
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发表时间：
2020-07-03
影响因子：
3.3
通讯作者：
Shmueli, Karin
中科院分区：
文献类型：
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作者：
Karsa, Anita;Punwani, Shonit;Shmueli, Karin
目的 定量敏感性图 (QSM) 是一种对疾病相关变化（包括氧合）敏感的新兴技术。它广泛用于大脑研究，并且在大脑以外的临床应用也越来越多。在这里，我们提出了第一个针对头颈部区域优化的 MRI 采集协议和 QSM 流程，以及在健康志愿者中进行的可重复性分析。方法 我们在 10 名受试者中研究了优化方法的会话内和会话间重复性。我们还实施了两种基于吉洪诺夫正则化的磁敏度计算技术，这些技术被发现比头颈部区域的现有方法具有更高的噪声对比度。通过计算重复扫描之间的敏感性差异分布和相应的最小可检测效应大小（MDE）来评估重复性。结果大脑深部区域比颈部区域具有更高的 QSM 重复性。正如预期的那样，会话内的可重复性通常优于会话间的可重复性。使用投影到偶极场上以去除背景场计算的磁化率图比在头颈部区域使用拉普拉斯边界值方法更具可重复性。小（短轴直径
Purpose Quantitative Susceptibility Mapping (QSM) is an emerging technique sensitive to disease-related changes including oxygenation. It is extensively used in brain studies and has increasing clinical applications outside the brain. Here we present the first MRI acquisition protocol and QSM pipeline optimized for the head-and-neck region together with a repeatability analysis performed in healthy volunteers. Methods We investigated both the intrasession and the intersession repeatability of the optimized method in 10 subjects. We also implemented two, Tikhonov-regularisation-based susceptibility calculation techniques that were found to have higher contrast-to-noise than existing methods in the head-and-neck region. Repeatability was evaluated by calculating the distributions of susceptibility differences between repeated scans and the corresponding minimum detectable effect sizes (MDEs). Results Deep brain regions had higher QSM repeatability than neck regions. As expected, intrasession repeatability was generally better than intersession repeatability. Susceptibility maps calculated using projection onto dipole fields for background field removal were more repeatable than using the Laplacian boundary value method in the head-and-neck region. Small (short-axis diameter